Literature DB >> 24996188

Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases.

Sunyi Lee1, Sora Han1, Ae Lee Jeong1, Jeong Su Park1, Young Yang2.   

Abstract

IK is known to inhibit the expression of major histocompatibility complex (MHC) class II antigen, but other cellular functions of IK remain to be uncovered. In this study, IK depletion caused misalignment of chromosomes through an increase in Aurora A and PLK1 phosphorylation, which was mediated by a decrease in PP1 and PP2A activities. On the other hand, the treatment of a dual inhibitor against CDK and Aurora kinases overrode IK depletion-induced mitotic arrest through the activation of phosphatase activity. These findings imply that IK is an essential protein for achieving correct mitotic progress through the regulation of mitotic kinases and phosphatases.
Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Aurora A; CDK1; IK; Mitotic arrest; Protein phosphatase

Mesh：

Substances：

Year:  2014        PMID： 24996188     DOI： 10.1016/j.febslet.2014.06.046

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA.

Authors:  Hye In Ka; Sunyi Lee; Sora Han; Ae Lee Jeong; Ji Young Park; Hyun Jeong Joo; Su Jung Soh; Doyeon Park; Young Yang
Journal:  Cell Death Discov       Date:  2020-05-04

2.  IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells.

Authors:  Sunyi Lee; Ae Lee Jeong; Jeong Su Park; Sora Han; Chang-Young Jang; Keun Il Kim; Yonghwan Kim; Jong Hoon Park; Jong-Seok Lim; Myung Sok Lee; Young Yang
Journal:  Cell Mol Life Sci       Date:  2016-02-23       Impact factor: 9.261

3.  Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway.

Authors:  Ae Lee Jeong; Sora Han; Sunyi Lee; Jeong Su Park; Yiling Lu; Shuangxing Yu; Jane Li; Kyung-Hee Chun; Gordon B Mills; Young Yang
Journal:  Sci Rep       Date:  2016-06-07       Impact factor: 4.379

4.  Ultrastructural Localization and Molecular Associations of HCV Capsid Protein in Jurkat T Cells.

Authors:  Cecilia Fernández-Ponce; Maria C Durán-Ruiz; Isaac Narbona-Sánchez; Juan P Muñoz-Miranda; Mikel M Arbulo-Echevarria; Antonio Serna-Sanz; Christian Baumann; Rocío Litrán; Enrique Aguado; Wilhelm Bloch; Francisco García-Cozar
Journal:  Front Microbiol       Date:  2018-01-04       Impact factor: 5.640

5.  Loss of splicing factor IK impairs normal skeletal muscle development.

Authors:  Hye In Ka; Hyemin Seo; Youngsook Choi; Joohee Kim; Mina Cho; Seok-Yong Choi; Sujeong Park; Sora Han; Jinsu An; Hak Suk Chung; Young Yang; Min Jung Kim
Journal:  BMC Biol       Date:  2021-04-01       Impact factor: 7.431

6.  Inactivating Mutations of the IK Gene Weaken Ku80/Ku70-Mediated DNA Repair and Sensitize Endometrial Cancer to Chemotherapy.

Authors:  Chao Gao; Guangxu Jin; Elizabeth Forbes; Lingegowda S Mangala; Yingmei Wang; Cristian Rodriguez-Aguayo; Paola Amero; Emine Bayraktar; Ye Yan; Gabriel Lopez-Berestein; Russell R Broaddus; Anil K Sood; Fengxia Xue; Wei Zhang
Journal:  Cancers (Basel)       Date:  2021-05-20       Impact factor: 6.639

7.  Eupatolide inhibits the TGF-β1-induced migration of breast cancer cells via downregulation of SMAD3 phosphorylation and transcriptional repression of ALK5.

Authors:  Ariundavaa Boldbaatar; Sunyi Lee; Sora Han; Ae Lee Jeong; Hye In Ka; Sumiyasuren Buyanravjikh; Jeong Hyung Lee; Jong-Seok Lim; Myung Sok Lee; Young Yang
Journal:  Oncol Lett       Date:  2017-09-15       Impact factor: 2.967

8.  Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA.

Authors:  Hye In Ka; Sunyi Lee; Sora Han; Ae Lee Jeong; Ji Young Park; Hyun Jeong Joo; Su Jung Soh; Doyeon Park; Young Yang
Journal:  Cell Death Discov       Date:  2020-05-04
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.