Literature DB >> 24995972

A mitochondrial expatriate: nuclear pyruvate dehydrogenase.

Vincent C J de Boer1, Sander M Houten2.   

Abstract

The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24995972     DOI： 10.1016/j.cell.2014.06.018

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  8 in total

Review 1.  Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis.

Authors:  I F Duarte; J Caio; M F Moedas; L A Rodrigues; A P Leandro; I A Rivera; M F B Silva
Journal:  Cell Mol Life Sci       Date:  2021-10-31       Impact factor: 9.261

2.  Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation.

Authors:  Jiao-Jiao Zhang; Ting-Ting Fan; Yun-Zi Mao; Jun-Li Hou; Meng Wang; Min Zhang; Yan Lin; Lei Zhang; Guo-Quan Yan; Yan-Peng An; Jun Yao; Cheng Zhang; Peng-Cheng Lin; Yi-Yuan Yuan; Jian-Yuan Zhao; Wei Xu; Shi-Min Zhao
Journal:  Nat Metab       Date:  2021-06-17

Review 3.  Metabolic reprogramming and epigenetic modifications on the path to cancer.

Authors:  Linchong Sun; Huafeng Zhang; Ping Gao
Journal:  Protein Cell       Date:  2021-05-29       Impact factor: 15.328

Review 4.  Microbiota and Neurological Disorders: A Gut Feeling.

Authors:  Walter H Moos; Douglas V Faller; David N Harpp; Iphigenia Kanara; Julie Pernokas; Whitney R Powers; Kosta Steliou
Journal:  Biores Open Access       Date:  2016-05-01

5.  The plasticity of the pyruvate dehydrogenase complex confers a labile structure that is associated with its catalytic activity.

Authors:  Jaehyoun Lee; Seunghee Oh; Saikat Bhattacharya; Ying Zhang; Laurence Florens; Michael P Washburn; Jerry L Workman
Journal:  PLoS One       Date:  2020-12-28       Impact factor: 3.240

6.  Mitochondria as a Platform for Dictating the Cell Fate of Cultured Human Corneal Endothelial Cells.

Authors:  Kohsaku Numa; Morio Ueno; Tomoko Fujita; Koji Ueda; Nao Hiramoto; Atushi Mukai; Yuichi Tokuda; Masakazu Nakano; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
Journal:  Invest Ophthalmol Vis Sci       Date:  2020-12-01       Impact factor: 4.799

7.  p-STAT3 is a PDC-E2 interacting partner in human cholangiocytes and hepatocytes with potential pathobiological implications.

Authors:  Ewa Kilanczyk; Jesus M Banales; Ewelina Jurewicz; Piotr Milkiewicz; Malgorzata Milkiewicz
Journal:  Sci Rep       Date:  2021-11-04       Impact factor: 4.379

Review 8.  The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells.

Authors:  Edward V Prochownik; Huabo Wang
Journal:  Cells       Date:  2021-03-30       Impact factor: 6.600
  8 in total

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