Claramae Shulyn Chia1,2, Whee Sze Ong3, Xin Jian Li4,5, Yoke-Lim Soong6, Fui Teen Chong2, Hiang-Khoon Tan1,2, Khee-Chee Soo1, Chao-Nan Qian4,5, Bin-Tean Teh4, N Gopalakrishna Iyer1,2. 1. Department of Surgical Oncology, National Cancer Centre Singapore, Singapore. 2. Wee Kim Wee Laboratory of Surgical Oncology, National Cancer Centre Singapore, Singapore. 3. Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, Singapore. 4. National Cancer Centre Singapore-VARI Translational Research Program, National Cancer Centre Singapore, Singapore. 5. State Key Laboratory of Oncology, Sun Yat-sen University Cancer Centre, Guangzhou, Guangzhou, China. 6. Department of Radiation Oncology, National Cancer Centre Singapore, Singapore.
Abstract
BACKGROUND: Nasopharyngeal carcinoma (NPC) has a high propensity for metastasis. The purpose of this study was for us to determine whether serglycin expression can be used to predict distant metastases. METHODS: Serglycin expression of tumor tissue of 112 patients with NPC was assessed based on percentage of tumor cells expressing serglycin, staining intensity, percentage of tumor-infiltrated lymphocyte (TIL) expressing serglycin and TIL-staining intensity. RESULTS: Risk factors for distant metastases include sex, smoking status, tumor intensity, and TIL percentage for serglycin. The odds of distant metastases was 4.13 and 0.18 in patients with strong tumor intensity and >50% TIL percentage, respectively. Based on a nomogram incorporating predictors, patients were stratified into 2 prognostic groups. The proportion of distant metastases in the high-risk group (strong tumor intensity and ≤50% TIL percentage) was 78% versus 19% in the low risk group (p < .001). CONCLUSION: Patients with NPC with tumors showing strong tumor intensity and low TIL percentage with serglycin may be at high risk for distant metastases.
BACKGROUND:Nasopharyngeal carcinoma (NPC) has a high propensity for metastasis. The purpose of this study was for us to determine whether serglycin expression can be used to predict distant metastases. METHODS:Serglycin expression of tumor tissue of 112 patients with NPC was assessed based on percentage of tumor cells expressing serglycin, staining intensity, percentage of tumor-infiltrated lymphocyte (TIL) expressing serglycin and TIL-staining intensity. RESULTS: Risk factors for distant metastases include sex, smoking status, tumor intensity, and TIL percentage for serglycin. The odds of distant metastases was 4.13 and 0.18 in patients with strong tumor intensity and >50% TIL percentage, respectively. Based on a nomogram incorporating predictors, patients were stratified into 2 prognostic groups. The proportion of distant metastases in the high-risk group (strong tumor intensity and ≤50% TIL percentage) was 78% versus 19% in the low risk group (p < .001). CONCLUSION:Patients with NPC with tumors showing strong tumor intensity and low TIL percentage with serglycin may be at high risk for distant metastases.
Authors: Yun Zhu; Alfred K Y Lam; Daisy K Y Shum; Di Cui; Jun Zhang; Dong Dong Yan; Bin Li; Wen Wen Xu; Nikki P Y Lee; Kin Tak Chan; Simon Law; Sai Wah Tsao; Annie L M Cheung Journal: Theranostics Date: 2021-01-01 Impact factor: 11.556