Mehmet Demir1, Canan Demir2, Serdar Keçeoğlu1. 1. Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital Bursa, Turkey. 2. Department of Infectious Disease, Bursa Şevket Yılmaz Education and Research Hospital Bursa, Turkey.
Abstract
BACKGROUND: Although nondipper hypertension has been associated with increased cardiovascular morbidity and mortality, the relationship between bilirubin levels and nondipper hypertension remains unclear. Several studies have demonstrated that higher serum bilirubin levels inhibit inflammation and the proliferation of vascular smooth muscle cells, which may suggest a relationship between serum bilirubin levels and cardiovascular disease. The aim of this study was to compare serum bilirubin levels between dipper and nondipper hypertensive patients. METHODS: The present study included 80 hypertensive patients who were stratified into two groups: 50 dipper patients (mean [± SD] age 51.5 ± 8 years; 29 male) and 30 nondipper patients (mean age 50.6 ± 5.4 years; 17 male). All patients underwent 24 h ambulatory blood pressure monitoring. RESULTS: No statistically significant differences were found between the two groups in terms of basic characteristics. Total, direct and indirect serum bilirubin levels were significantly lower among individuals with nondipper hypertension compared with patients with dipper hypertension (0.78 ± 0.6 mg/dL versus 0.42 ± 0.32 mg/dL; and 0.29 ± 0.1 mg/dL versus 0.18 ± 0.05 mg/dL; and 0.48 ± 0.52 mg/dL versus 0.25 ± 0.22 mg/dL, respectively; all P<0.001). Additionally, leukocyte counts were higher in patients with nondipper hypertension. CONCLUSION: The present study revealed a potential relationship between lower serum bilirubin levels and a nondipping pattern in hypertensive patients.
BACKGROUND: Although nondipper hypertension has been associated with increased cardiovascular morbidity and mortality, the relationship between bilirubin levels and nondipper hypertension remains unclear. Several studies have demonstrated that higher serum bilirubin levels inhibit inflammation and the proliferation of vascular smooth muscle cells, which may suggest a relationship between serum bilirubin levels and cardiovascular disease. The aim of this study was to compare serum bilirubin levels between dipper and nondipper hypertensivepatients. METHODS: The present study included 80 hypertensivepatients who were stratified into two groups: 50 dipperpatients (mean [± SD] age 51.5 ± 8 years; 29 male) and 30 nondipper patients (mean age 50.6 ± 5.4 years; 17 male). All patients underwent 24 h ambulatory blood pressure monitoring. RESULTS: No statistically significant differences were found between the two groups in terms of basic characteristics. Total, direct and indirect serum bilirubin levels were significantly lower among individuals with nondipper hypertension compared with patients with dipper hypertension (0.78 ± 0.6 mg/dL versus 0.42 ± 0.32 mg/dL; and 0.29 ± 0.1 mg/dL versus 0.18 ± 0.05 mg/dL; and 0.48 ± 0.52 mg/dL versus 0.25 ± 0.22 mg/dL, respectively; all P<0.001). Additionally, leukocyte counts were higher in patients with nondipper hypertension. CONCLUSION: The present study revealed a potential relationship between lower serum bilirubin levels and a nondipping pattern in hypertensivepatients.
Authors: Eoin O'Brien; Gianfranco Parati; George Stergiou; Roland Asmar; Laurie Beilin; Grzegorz Bilo; Denis Clement; Alejandro de la Sierra; Peter de Leeuw; Eamon Dolan; Robert Fagard; John Graves; Geoffrey A Head; Yutaka Imai; Kazuomi Kario; Empar Lurbe; Jean-Michel Mallion; Giuseppe Mancia; Thomas Mengden; Martin Myers; Gbenga Ogedegbe; Takayoshi Ohkubo; Stefano Omboni; Paolo Palatini; Josep Redon; Luis M Ruilope; Andrew Shennan; Jan A Staessen; Gert vanMontfrans; Paolo Verdecchia; Bernard Waeber; Jiguang Wang; Alberto Zanchetti; Yuqing Zhang Journal: J Hypertens Date: 2013-09 Impact factor: 4.844
Authors: Libor Vítek; Milan Jirsa; Marie Brodanová; Milan Kalab; Zdenek Marecek; Vilém Danzig; Ladislav Novotný; Petr Kotal Journal: Atherosclerosis Date: 2002-02 Impact factor: 5.162
Authors: Robert Ollinger; Martin Bilban; Anna Erat; Alberto Froio; James McDaid; Shivraj Tyagi; Eva Csizmadia; Aurelio V Graça-Souza; Angela Liloia; Miguel P Soares; Leo E Otterbein; Anny Usheva; Kenichiro Yamashita; Fritz H Bach Journal: Circulation Date: 2005-08-08 Impact factor: 29.690
Authors: Douwe Dekker; Mirrin J Dorresteijn; Margot Pijnenburg; Suzanne Heemskerk; Anja Rasing-Hoogveld; David M Burger; Frank A D T G Wagener; Paul Smits Journal: Arterioscler Thromb Vasc Biol Date: 2010-11-18 Impact factor: 8.311