Se Eun Park1, Nam Seok Lee1, Ji Woo Park1, Eun-Jung Rhee1, Won-Young Lee1, Ki-Won Oh1, Sung-Woo Park1, Cheol-Young Park2, Byung-Soo Youn3. 1. Division of Endocrinology and MetabolismDepartment of Internal medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaAdipoGen, Inc.Room 401, Venture Building B, Songdo Technopark, 7-50 Songdo-dong, Yeonsu-gu, Incheon, Republic of KoreaDepartment of AnatomyWonkwang University School of Medicine, #22 Wonkwang Daehak-ro, Iksan, Jeollabuk-do 570-749, Republic of KoreaOsteoNeuroGen 40 MiKeum-ROBundang-Gu, Sungnam-City, Gyeonggi-do 461-871, Republic of Korea. 2. Division of Endocrinology and MetabolismDepartment of Internal medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaAdipoGen, Inc.Room 401, Venture Building B, Songdo Technopark, 7-50 Songdo-dong, Yeonsu-gu, Incheon, Republic of KoreaDepartment of AnatomyWonkwang University School of Medicine, #22 Wonkwang Daehak-ro, Iksan, Jeollabuk-do 570-749, Republic of KoreaOsteoNeuroGen 40 MiKeum-ROBundang-Gu, Sungnam-City, Gyeonggi-do 461-871, Republic of Korea cydoctor@chol.com byung4jc@gmail.com. 3. Division of Endocrinology and MetabolismDepartment of Internal medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaAdipoGen, Inc.Room 401, Venture Building B, Songdo Technopark, 7-50 Songdo-dong, Yeonsu-gu, Incheon, Republic of KoreaDepartment of AnatomyWonkwang University School of Medicine, #22 Wonkwang Daehak-ro, Iksan, Jeollabuk-do 570-749, Republic of KoreaOsteoNeuroGen 40 MiKeum-ROBundang-Gu, Sungnam-City, Gyeonggi-do 461-871, Republic of Korea Division of Endocrinology and MetabolismDepartment of Internal medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaAdipoGen, Inc.Room 401, Venture Building B, Songdo Technopark, 7-50 Songdo-dong, Yeonsu-gu, Incheon, Republic of KoreaDepartment of AnatomyWonkwang University School of Medicine, #22 Wonkwang Daehak-ro, Iksan, Jeollabuk-do 570-749, Republic of KoreaOsteoNeuroGen 40 MiKeum-ROBundang-Gu, Sungnam-City, Gyeonggi-do 461-871, Republic of Korea cydoctor@chol.com byung4jc@gmail.com.
Abstract
OBJECTIVE: Serum concentrations of retinol-binding protein 4 (RBP4) are elevated in type 2 diabetes and associated with the severity of insulin resistance; however, there are few data about the relationship between urinary RBP4 levels and metabolic parameters. We assessed urinary RBP4 as a new biomarker by establishing its relationship with clinical parameters associated with insulin resistance and urinary albumin excretion. DESIGN AND METHODS: We measured RBP4 in the serum and urine of 689 subjects with diverse glucose tolerance status. We also evaluated the relationship between urinary RBP4 and cardiometabolic risk factors, including insulin resistance, high-sensitivity C-reactive protein (hsCRP), arterial stiffness, and microalbuminuria. RESULTS: Urinary RBP4 levels were higher in insulin-resistant subjects with prediabetes or type 2 diabetes than in subjects with normal glucose tolerance (NGT) (type 2 diabetes>prediabetes>NGT; all P<0.001). Urinary RBP4 correlated strongly with homeostasis model assessments of insulin resistance (HOMA-IR), fasting glucose, triglycerides, blood pressure, hsCRP, arterial stiffness, estimated glomerular filtration rate, and urinary albumin-to-creatinine ratio (all P<0.01). HOMA-IR and arterial stiffness were found to be independent determinants of urinary RBP4 concentration. Furthermore, urinary RBP4 was highly predictive of microalbuminuria (odds ratio 2.6, 95% CI 1.6-4.2), even after adjustment for other metabolic parameters. The area under the ROC curve for urinary RBP4 to detect the presence of microalbuminuria was 0.80±0.02 (95% CI 0.76-0.84) and the cut-off value was 157.01 μg/gCr. CONCLUSIONS: Urinary RBP4 concentrations were elevated in patients with dysregulation of glucose metabolism and were related to various cardiometabolic risk factors including insulin resistance, inflammation, and microalbuminuria.
OBJECTIVE: Serum concentrations of retinol-binding protein 4 (RBP4) are elevated in type 2 diabetes and associated with the severity of insulin resistance; however, there are few data about the relationship between urinary RBP4 levels and metabolic parameters. We assessed urinary RBP4 as a new biomarker by establishing its relationship with clinical parameters associated with insulin resistance and urinary albumin excretion. DESIGN AND METHODS: We measured RBP4 in the serum and urine of 689 subjects with diverse glucose tolerance status. We also evaluated the relationship between urinary RBP4 and cardiometabolic risk factors, including insulin resistance, high-sensitivity C-reactive protein (hsCRP), arterial stiffness, and microalbuminuria. RESULTS: Urinary RBP4 levels were higher in insulin-resistant subjects with prediabetes or type 2 diabetes than in subjects with normal glucose tolerance (NGT) (type 2 diabetes>prediabetes>NGT; all P<0.001). Urinary RBP4 correlated strongly with homeostasis model assessments of insulin resistance (HOMA-IR), fasting glucose, triglycerides, blood pressure, hsCRP, arterial stiffness, estimated glomerular filtration rate, and urinary albumin-to-creatinine ratio (all P<0.01). HOMA-IR and arterial stiffness were found to be independent determinants of urinary RBP4 concentration. Furthermore, urinary RBP4 was highly predictive of microalbuminuria (odds ratio 2.6, 95% CI 1.6-4.2), even after adjustment for other metabolic parameters. The area under the ROC curve for urinary RBP4 to detect the presence of microalbuminuria was 0.80±0.02 (95% CI 0.76-0.84) and the cut-off value was 157.01 μg/gCr. CONCLUSIONS: Urinary RBP4 concentrations were elevated in patients with dysregulation of glucose metabolism and were related to various cardiometabolic risk factors including insulin resistance, inflammation, and microalbuminuria.
Authors: Justin P Zachariah; Susan Hwang; Naomi M Hamburg; Emelia J Benjamin; Martin G Larson; Daniel Levy; Joseph A Vita; Lisa M Sullivan; Gary F Mitchell; Ramachandran S Vasan Journal: Hypertension Date: 2015-11-30 Impact factor: 10.190
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Authors: Letizia Zeni; Anthony G W Norden; Elena Prandi; Carolina Canepa; Keith Burling; Katherine Simpson; Barbara Felappi; Alessandro Plebani; Giovanni Cancarini; Pietro Manuel Ferraro; Donald Fraser; Robert J Unwin Journal: Diabetol Metab Syndr Date: 2022-05-12 Impact factor: 5.395