George U Eleje1, Joseph I Adinma2, Samuel Ghasi3, Joseph I Ikechebelu2, Anthony O Igwegbe2, John E Okonkwo2, Charles I Okafor2, Chukwuemeka O Ezeama2, Ifeanyichukwu U Ezebialu4, Chukwuanugo N Ogbuagu5. 1. Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria. Electronic address: georgel21@yahoo.com. 2. Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria. 3. Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu, Nigeria. 4. Department of Obstetrics and Gynecology, Anambra State University Teaching Hospital, Awka, Nigeria. 5. Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka, Nigeria.
Abstract
OBJECTIVE: To identify microbes prevalent in the genital tract of pregnant women with preterm premature rupture of membranes (PPROM) and to assess the susceptibility of the microbial isolates to a range of antibiotics to determine appropriate antibiotics for treating cases of PPROM in resource-limited settings. METHODS: A prospective cross-sectional study was undertaken involving women with (n=105) and without (n=105) a confirmed diagnosis of PPROM admitted to Nnamdi Azikiwe University Teaching Hospital, southeast Nigeria, between January 1, 2011, and April 30, 2013. Endocervical swabs were collected from all participants and examined microbiologically. Antibiotic sensitivity testing was performed using Kirby-Bauer disk diffusion. RESULTS: Streptococcus spp., Staphylococcus aureus, and Escherichia coli were significantly more prevalent among women with PPROM than among those without PPROM (P<0.01). Among the antibiotics considered safe to use during pregnancy, the bacteria were most sensitive to ampicillin-sulbactam, cefixime, cefuroxime, and erythromycin. CONCLUSION: For the first 48hours, women with PPROM should receive an intravenous dose combining ampicillin-sulbactam, cefixime, cefuroxime, or erythromycin with metronidazole followed by oral administration of the chosen antibiotic combination to complete a 7-day course.
OBJECTIVE: To identify microbes prevalent in the genital tract of pregnant women with preterm premature rupture of membranes (PPROM) and to assess the susceptibility of the microbial isolates to a range of antibiotics to determine appropriate antibiotics for treating cases of PPROM in resource-limited settings. METHODS: A prospective cross-sectional study was undertaken involving women with (n=105) and without (n=105) a confirmed diagnosis of PPROM admitted to Nnamdi Azikiwe University Teaching Hospital, southeast Nigeria, between January 1, 2011, and April 30, 2013. Endocervical swabs were collected from all participants and examined microbiologically. Antibiotic sensitivity testing was performed using Kirby-Bauer disk diffusion. RESULTS: Streptococcus spp., Staphylococcus aureus, and Escherichia coli were significantly more prevalent among women with PPROM than among those without PPROM (P<0.01). Among the antibiotics considered safe to use during pregnancy, the bacteria were most sensitive to ampicillin-sulbactam, cefixime, cefuroxime, and erythromycin. CONCLUSION: For the first 48hours, women with PPROM should receive an intravenous dose combining ampicillin-sulbactam, cefixime, cefuroxime, or erythromycin with metronidazole followed by oral administration of the chosen antibiotic combination to complete a 7-day course.
Authors: George U Eleje; Euzebus C Ezugwu; Ifeanyichukwu U Ezebialu; Nnabuike O Ojiegbe; Richard O Egeonu; Chukwudi C Obiora; Chigozie G Okafor; Joseph I Ikechebelu; Ahizechukwu C Eke Journal: Int J Gynaecol Obstet Date: 2018-11-20 Impact factor: 4.447
Authors: Ryan S Doster; Leslie A Kirk; Lauren M Tetz; Lisa M Rogers; David M Aronoff; Jennifer A Gaddy Journal: J Infect Dis Date: 2017-02-15 Impact factor: 5.226
Authors: George U Eleje; Ahizechukwu C Eke; Joseph I Ikechebelu; Ifeanyichukwu U Ezebialu; Princeston C Okam; Chito P Ilika Journal: Cochrane Database Syst Rev Date: 2020-09-24