Literature DB >> 24994111

microRNA‑802 promotes lung carcinoma proliferation by targeting the tumor suppressor menin.

Lun-Qing Wang1, Gang Chen1, Xiang-Yan Liu1, Fan-Ying Liu1, Shao-Yan Jiang2, Zhou Wang1.   

Abstract

microRNAs play important roles in numerous biological processes, including tumorigenesis, by modulating critical gene transcripts. In the present study, the role of microRNA‑802 (miR‑802) in lung cancer was investigated. The results of the quantitative polymerase chain reaction revealed that expression levels of miR‑802 were significantly upregulated in lung cancer tissues. In vitro experiments demonstrated that miR‑802 promoted cell proliferation in A549, NCI‑H358 and NCI‑H1299 cells. Furthermore, it was indicated that miR‑802 promoted the proliferation of lung carcinoma by targeting the tumor suppressor menin. Therefore, these results suggest a previously unknown miR‑802/menin molecular network controlling lung carcinoma development.

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Year:  2014        PMID: 24994111     DOI: 10.3892/mmr.2014.2361

Source DB:  PubMed          Journal:  Mol Med Rep        ISSN: 1791-2997            Impact factor:   2.952


  11 in total

1.  A microRNA cluster (let-7c, miRNA-99a, miRNA-125b, miRNA-155 and miRNA-802) encoded at chr21q21.1-chr21q21.3 and the phenotypic diversity of Down's syndrome (DS; trisomy 21).

Authors:  Yuhai Zhao; Vivian Jaber; Maire E Percy; Walter J Lukiw
Journal:  J Nat Sci       Date:  2017-09

2.  Chromosome 21-Encoded microRNAs (mRNAs): Impact on Down's Syndrome and Trisomy-21 Linked Disease.

Authors:  P N Alexandrov; M E Percy; Walter J Lukiw
Journal:  Cell Mol Neurobiol       Date:  2017-07-07       Impact factor: 5.046

3.  A microRNA Signature Identifies Patients at Risk of Barrett Esophagus Progression to Dysplasia and Cancer.

Authors:  James Saller; Kun Jiang; Yin Xiong; Sean J Yoder; Kevin Neill; Jose M Pimiento; Luis Pena; F Scott Corbett; Anthony Magliocco; Domenico Coppola
Journal:  Dig Dis Sci       Date:  2021-03-13       Impact factor: 3.199

4.  MiRNA-802 suppresses proliferation and migration of epithelial ovarian cancer cells by targeting YWHAZ.

Authors:  Bo Yang; Li Sun; Lei Liang
Journal:  J Ovarian Res       Date:  2019-10-22       Impact factor: 4.234

5.  MiR-802 Suppresses Colorectal Cancer Cell Viability, Migration and Invasion by Targeting RAN.

Authors:  Hailong Feng; Lingling Liu; Laijing Xu; Haili Wang; Qiuju Hua; Peng He
Journal:  Cancer Manag Res       Date:  2020-03-26       Impact factor: 3.989

6.  miR‑802 inhibits the epithelial‑mesenchymal transition, migration and invasion of cervical cancer by regulating BTF3.

Authors:  Xiuhui Wu; Leng Liu; Hongxia Zhang
Journal:  Mol Med Rep       Date:  2020-06-23       Impact factor: 2.952

7.  Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer.

Authors:  Sören Müller; Susanne Raulefs; Philipp Bruns; Fabian Afonso-Grunz; Anne Plötner; Rolf Thermann; Carsten Jäger; Anna Melissa Schlitter; Bo Kong; Ivonne Regel; W Kurt Roth; Björn Rotter; Klaus Hoffmeier; Günter Kahl; Ina Koch; Fabian J Theis; Jörg Kleeff; Peter Winter; Christoph W Michalski
Journal:  Mol Cancer       Date:  2015-04-25       Impact factor: 27.401

8.  Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer.

Authors:  Azadeh Azizian; Ingo Epping; Frank Kramer; Peter Jo; Markus Bernhardt; Julia Kitz; Gabriela Salinas; Hendrik A Wolff; Marian Grade; Tim Beißbarth; B Michael Ghadimi; Jochen Gaedcke
Journal:  Int J Mol Sci       Date:  2016-04-15       Impact factor: 5.923

9.  MiR-15a/miR-16-1 expression inversely correlates with cyclin D1 levels in Men1 pituitary NETs.

Authors:  Kate E Lines; Paul J Newey; Christopher J Yates; Mark Stevenson; Rebecca Dyar; Gerard V Walls; Mike R Bowl; Rajesh V Thakker
Journal:  J Endocrinol       Date:  2018-09-01       Impact factor: 4.286

10.  MicroRNA-802 Suppresses Tumorigenesis of Colorectal Cancer via Regulating UBN2.

Authors:  Tao Yang; Qiuying Guo; Dongsheng Li; Guang Bai; Hongzhi Sun; Wei Wang
Journal:  Cancer Manag Res       Date:  2020-11-04       Impact factor: 3.989

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