| Literature DB >> 24993870 |
Yao Zhang1, Lijuan Zhao1, Xiaojiang Guo1, Chao Li1, Haizhen Li1, Hongxiang Lou1, Dongmei Ren2.
Abstract
Two new compounds (1-2), including a bisabolane-type sesquiterpenoid (1), one new diphenyl ether derivative (2), together with 23 known compounds (3-25), were isolated from the fruits of Phyllanthus emblica. Their structures were elucidated by detailed spectroscopic analysis. All the isolated compounds were screened for the DPPH scavenging effects and cytoprotective effects against H2O2 induced PC12 cells injury. Compounds 12-15 showed significant DPPH scavenging effects with the IC50 values in the range of 3.25-4.18 μM. Among these potential antioxidants, compound 14 improved the survival of PC12 cells after H2O2 exposure without showing any cytotoxicity at the tested concentrations.Entities:
Keywords: Bisabolane-type sesquiterpenoid; Cytoprotection; Diphenyl ether derivative; Phyllanthus emblica
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Year: 2014 PMID： 24993870 DOI： 10.1007/s12272-014-0433-2
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946