I Toprak1, V Yaylalı2, C Yildirim2. 1. Department of Ophthalmology, Servergazi State Hospital, Denizli, Turkey. 2. Department of Ophthalmology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Abstract
PURPOSE: To assess the effects of idiopathic epimacular membrane (IEMM) on retinal pigment epithelium (RPE), photoreceptor inner segment/outer segment (IS/OS) junction, and external limiting membrane (ELM) reflectivities to determine functional alterations in these layers using optical coherence tomography (OCT) image analysis. METHODS: Fifty eyes of 50 patients with untreated IEMM and 41 eyes of 41 age- and sex-matched healthy controls with normal OCT scans were retrospectively reviewed. A single masked physician analyzed OCT images randomly. Reflectivity values of RPE, IS/OS junction, and ELM were obtained using 'plot profile' mode of a medical image processing computer software. RESULTS: The study comprised 50 patients with untreated IEMM and age- and sex-matched 41 control subjects (P > 0.05). Image analysis demonstrated that IS/OS junction and ELM had significantly lower reflectivity in patients with IEMM compared with those of the control eyes (P = 0.008, P = 0.009, respectively). However, RPE reflectivity did not differ between two groups (P = 0.100). Correlation analyses showed no significant associations between reflectivity values and corrected visual acuity (P > 0.05). CONCLUSION: In patients with IEMM, photoreceptor IS/OS junction and ELM seem to have lower reflectivity, which might indicate impaired functionality even though these layers are not apparently damaged on OCT imaging.
PURPOSE: To assess the effects of idiopathic epimacular membrane (IEMM) on retinal pigment epithelium (RPE), photoreceptor inner segment/outer segment (IS/OS) junction, and external limiting membrane (ELM) reflectivities to determine functional alterations in these layers using optical coherence tomography (OCT) image analysis. METHODS: Fifty eyes of 50 patients with untreated IEMM and 41 eyes of 41 age- and sex-matched healthy controls with normal OCT scans were retrospectively reviewed. A single masked physician analyzed OCT images randomly. Reflectivity values of RPE, IS/OS junction, and ELM were obtained using 'plot profile' mode of a medical image processing computer software. RESULTS: The study comprised 50 patients with untreated IEMM and age- and sex-matched 41 control subjects (P > 0.05). Image analysis demonstrated that IS/OS junction and ELM had significantly lower reflectivity in patients with IEMM compared with those of the control eyes (P = 0.008, P = 0.009, respectively). However, RPE reflectivity did not differ between two groups (P = 0.100). Correlation analyses showed no significant associations between reflectivity values and corrected visual acuity (P > 0.05). CONCLUSION: In patients with IEMM, photoreceptor IS/OS junction and ELM seem to have lower reflectivity, which might indicate impaired functionality even though these layers are not apparently damaged on OCT imaging.
Authors: K Bizheva; R Pflug; B Hermann; B Povazay; H Sattmann; P Qiu; E Anger; H Reitsamer; S Popov; J R Taylor; A Unterhuber; P Ahnelt; W Drexler Journal: Proc Natl Acad Sci U S A Date: 2006-03-21 Impact factor: 11.205
Authors: Zach Nadler; Bo Wang; Gadi Wollstein; Jessica E Nevins; Hiroshi Ishikawa; Richard Bilonick; Larry Kagemann; Ian A Sigal; R Daniel Ferguson; Ankit Patel; Daniel X Hammer; Joel S Schuman Journal: Biomed Opt Express Date: 2014-03-10 Impact factor: 3.732
Authors: W E Smiddy; A M Maguire; W R Green; R G Michels; Z de la Cruz; C Enger; M Jaeger; T A Rice Journal: Ophthalmology Date: 1989-06 Impact factor: 12.079
Authors: Samantha Fraser-Bell; Magdalena Guzowski; Elena Rochtchina; Jie Jin Wang; Paul Mitchell Journal: Ophthalmology Date: 2003-01 Impact factor: 12.079