BACKGROUND/ OBJECTIVE: To evaluate if fundus autofluorescence (FAF) patterns around geographic atrophy (GA) and the status of the fellow eye have an impact on GA progression. METHODS: We included 54 eyes of 35 patients with GA. Areas of GA were quantified by RegionFinder software. RESULTS: GA progression rates in eyes with a diffuse trickling pattern (median 1.42 mm(2)/year) were significantly higher than in normal eyes (median 0.22 mm(2)/year) and eyes with other diffuse FAF patterns (median 0.46 mm(2)/year). Eyes with a banded pattern had a significantly higher progression rate (median 0.81 mm(2)/year) than those without any FAF abnormalities (p = 0.038). The group with baseline total atrophy of the eyes <1 disk area (DA; median 0.42 mm(2)) had an inverse relation with GA progression compared to the groups with baseline atrophy >1 DA (p < 0.05). CONCLUSION: Diffuse trickling and banded patterns may have an impact on GA progression and may serve as prognostic factors.
BACKGROUND/ OBJECTIVE: To evaluate if fundus autofluorescence (FAF) patterns around geographic atrophy (GA) and the status of the fellow eye have an impact on GA progression. METHODS: We included 54 eyes of 35 patients with GA. Areas of GA were quantified by RegionFinder software. RESULTS: GA progression rates in eyes with a diffuse trickling pattern (median 1.42 mm(2)/year) were significantly higher than in normal eyes (median 0.22 mm(2)/year) and eyes with other diffuse FAF patterns (median 0.46 mm(2)/year). Eyes with a banded pattern had a significantly higher progression rate (median 0.81 mm(2)/year) than those without any FAF abnormalities (p = 0.038). The group with baseline total atrophy of the eyes <1 disk area (DA; median 0.42 mm(2)) had an inverse relation with GA progression compared to the groups with baseline atrophy >1 DA (p < 0.05). CONCLUSION: Diffuse trickling and banded patterns may have an impact on GA progression and may serve as prognostic factors.
Authors: Karl G Csaky; Praveen J Patel; Yasir J Sepah; David G Birch; Diana V Do; Michael S Ip; Robyn H Guymer; Chi D Luu; Shamika Gune; Hugh Lin; Daniela Ferrara Journal: Surv Ophthalmol Date: 2019-01-28 Impact factor: 6.048
Authors: Thomas J Heesterbeek; Laura Lorés-Motta; Carel B Hoyng; Yara T E Lechanteur; Anneke I den Hollander Journal: Ophthalmic Physiol Opt Date: 2020-02-25 Impact factor: 3.117