Literature DB >> 24993071

New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells.

Mira Jeong1, Margaret A Goodell2.   

Abstract

DNA methylation is a well-studied epigenetic modification essential for efficient cellular differentiation. Aberrant DNA methylation patterns are a characteristic feature of cancer, including myeloid malignancies such as acute myeloid leukemia. Recurrent mutations in DNA-modifying enzymes were identified in acute myeloid leukemia and linked to distinct DNA methylation signatures. In addition, discovery of Tet enzymes provided new mechanisms for the reversal of DNA methylation. Advances in base-resolution profiling of DNA methylation have enabled a more comprehensive understanding of the methylome landscape in the genome. This review will summarize and discuss the key questions in the function of DNA methylation in the hematopoietic system, including where and how DNA methylation regulates diverse biological processes in the genome as elucidated by recent studies.
Copyright © 2014 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24993071      PMCID： PMC4137036          DOI： 10.1016/j.exphem.2014.04.008

Source DB:  PubMed          Journal:  Exp Hematol        ISSN： 0301-472X            Impact factor:   3.084


  101 in total

Review 1.  CpG islands and the regulation of transcription.

Authors:  Aimée M Deaton; Adrian Bird
Journal:  Genes Dev       Date:  2011-05-15       Impact factor: 11.361

2.  Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.

Authors:  Hao Wu; Ana C D'Alessio; Shinsuke Ito; Kai Xia; Zhibin Wang; Kairong Cui; Keji Zhao; Yi Eve Sun; Yi Zhang
Journal:  Nature       Date:  2011-03-30       Impact factor: 49.962

3.  Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.

Authors:  William A Pastor; Utz J Pape; Yun Huang; Hope R Henderson; Ryan Lister; Myunggon Ko; Erin M McLoughlin; Yevgeny Brudno; Sahasransu Mahapatra; Philipp Kapranov; Mamta Tahiliani; George Q Daley; X Shirley Liu; Joseph R Ecker; Patrice M Milos; Suneet Agarwal; Anjana Rao
Journal:  Nature       Date:  2011-05-08       Impact factor: 49.962

4.  Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.

Authors:  Kian Peng Koh; Akiko Yabuuchi; Sridhar Rao; Yun Huang; Kerrianne Cunniff; Julie Nardone; Asta Laiho; Mamta Tahiliani; Cesar A Sommer; Gustavo Mostoslavsky; Riitta Lahesmaa; Stuart H Orkin; Scott J Rodig; George Q Daley; Anjana Rao
Journal:  Cell Stem Cell       Date:  2011-02-04       Impact factor: 24.633

5.  Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.

Authors:  Chun-Xiao Song; Keith E Szulwach; Ye Fu; Qing Dai; Chengqi Yi; Xuekun Li; Yujing Li; Chih-Hsin Chen; Wen Zhang; Xing Jian; Jing Wang; Li Zhang; Timothy J Looney; Baichen Zhang; Lucy A Godley; Leslie M Hicks; Bruce T Lahn; Peng Jin; Chuan He
Journal:  Nat Biotechnol       Date:  2010-12-12       Impact factor: 54.908

6.  Human epigenome data reveal increased CpG methylation in alternatively spliced sites and putative exonic splicing enhancers.

Authors:  Christina Anastasiadou; Andigoni Malousi; Nicos Maglaveras; Sofia Kouidou
Journal:  DNA Cell Biol       Date:  2011-05       Impact factor: 3.311

7.  DNMT3A mutations in acute myeloid leukemia.

Authors:  Timothy J Ley; Li Ding; Matthew J Walter; Michael D McLellan; Tamara Lamprecht; David E Larson; Cyriac Kandoth; Jacqueline E Payton; Jack Baty; John Welch; Christopher C Harris; Cheryl F Lichti; R Reid Townsend; Robert S Fulton; David J Dooling; Daniel C Koboldt; Heather Schmidt; Qunyuan Zhang; John R Osborne; Ling Lin; Michelle O'Laughlin; Joshua F McMichael; Kim D Delehaunty; Sean D McGrath; Lucinda A Fulton; Vincent J Magrini; Tammi L Vickery; Jasreet Hundal; Lisa L Cook; Joshua J Conyers; Gary W Swift; Jerry P Reed; Patricia A Alldredge; Todd Wylie; Jason Walker; Joelle Kalicki; Mark A Watson; Sharon Heath; William D Shannon; Nobish Varghese; Rakesh Nagarajan; Peter Westervelt; Michael H Tomasson; Daniel C Link; Timothy A Graubert; John F DiPersio; Elaine R Mardis; Richard K Wilson
Journal:  N Engl J Med       Date:  2010-11-10       Impact factor: 91.245

8.  Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.

Authors:  Xiao-Jing Yan; Jie Xu; Zhao-Hui Gu; Chun-Ming Pan; Gang Lu; Yang Shen; Jing-Yi Shi; Yong-Mei Zhu; Lin Tang; Xiao-Wei Zhang; Wen-Xue Liang; Jian-Qing Mi; Huai-Dong Song; Ke-Qin Li; Zhu Chen; Sai-Juan Chen
Journal:  Nat Genet       Date:  2011-03-13       Impact factor: 38.330

9.  Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.

Authors:  Myunggon Ko; Yun Huang; Anna M Jankowska; Utz J Pape; Mamta Tahiliani; Hozefa S Bandukwala; Jungeun An; Edward D Lamperti; Kian Peng Koh; Rebecca Ganetzky; X Shirley Liu; L Aravind; Suneet Agarwal; Jaroslaw P Maciejewski; Anjana Rao
Journal:  Nature       Date:  2010-12-09       Impact factor: 49.962

10.  Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates.

Authors:  Daniel Globisch; Martin Münzel; Markus Müller; Stylianos Michalakis; Mirko Wagner; Susanne Koch; Tobias Brückl; Martin Biel; Thomas Carell
Journal:  PLoS One       Date:  2010-12-23       Impact factor: 3.240
View more
  16 in total

Review 1.  Mammalian DNA methyltransferases: new discoveries and open questions.

Authors:  Humaira Gowher; Albert Jeltsch
Journal:  Biochem Soc Trans       Date:  2018-08-28       Impact factor: 5.407

2.  Dnmt3b Methylates DNA by a Noncooperative Mechanism, and Its Activity Is Unaffected by Manipulations at the Predicted Dimer Interface.

Authors:  Allison B Norvil; Christopher J Petell; Lama Alabdi; Lanchen Wu; Sandra Rossie; Humaira Gowher
Journal:  Biochemistry       Date:  2016-11-04       Impact factor: 3.162

Review 3.  The TET2 interactors and their links to hematological malignancies.

Authors:  Feng Pan; Ophelia Weeks; Feng-Chun Yang; Mingjiang Xu
Journal:  IUBMB Life       Date:  2015-06-22       Impact factor: 3.885

Review 4.  Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications.

Authors:  Daniel Desaulniers; Paule Vasseur; Abigail Jacobs; M Cecilia Aguila; Norman Ertych; Miriam N Jacobs
Journal:  Int J Mol Sci       Date:  2021-10-11       Impact factor: 5.923

5.  Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.

Authors:  N Hasegawa; M Oshima; G Sashida; H Matsui; S Koide; A Saraya; C Wang; T Muto; K Takane; A Kaneda; K Shimoda; C Nakaseko; K Yokote; A Iwama
Journal:  Leukemia       Date:  2016-10-03       Impact factor: 11.528

6.  Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation.

Authors:  Maria Armila Ruiz; Angela Rivers; Vinzon Ibanez; Kestis Vaitkus; Nadim Mahmud; Joseph DeSimone; Donald Lavelle
Journal:  Epigenetics       Date:  2015       Impact factor: 4.528

7.  Decreased mRNA expression levels of DNA methyltransferases type 1 and 3A in systemic lupus erythematosus.

Authors:  Mariusz J Nawrocki; Dominik Majewski; Mariusz Puszczewicz; Paweł P Jagodziński
Journal:  Rheumatol Int       Date:  2017-03-27       Impact factor: 2.631

Review 8.  The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms.

Authors:  K J Hewitt; K D Johnson; X Gao; S Keles; E H Bresnick
Journal:  Curr Top Dev Biol       Date:  2016-02-26       Impact factor: 4.897

9.  CTNNA1 hypermethylation, a frequent event in acute myeloid leukemia, is independently associated with an adverse outcome.

Authors:  Mianyang Li; Li Gao; Zhenling Li; Junzhong Sun; Hui Zhang; Haoqing Duan; Yigai Ma; Chengbin Wang
Journal:  Oncotarget       Date:  2016-05-24

10.  Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq.

Authors:  Wenji Li; Ying Huang; Davit Sargsyan; Tin Oo Khor; Yue Guo; Limin Shu; Anne Yuqing Yang; Chengyue Zhang; Ximena Paredes-Gonzalez; Michael Verzi; Ronald P Hart; Ah-Ng Kong
Journal:  Cell Biosci       Date:  2018-01-12       Impact factor: 7.133
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.