AIM: The aim of this study was to investigate the anti-fungal activity of Morinda citrifolia fruit extract on Candida albicans. MATERIALS AND METHODS: Juice extract from M. citrifolia fruit was lyophilized and used in anti-fungal testing. Anti-fungal activity of M. citrifolia fruit extract against C. albicans was tested in vitro at various concentrations. The inhibitory effect of M. citrifolia extract on C. albicans was determined by agar culture and applied broth dilution test. RESULTS: M. citrifolia extract at 1000 μg/ml concentration effectively inhibited the growth of C. albicans (16.6 ± 0.3) compared with the positive control - amphotericin B (20.6 ± 0.6). It was found to be a dose-dependent reaction. CONCLUSION: M. citrifolia fruit extract had an anti-fungal effect on C. albicans and the inhibitory effect varied with concentration.
AIM: The aim of this study was to investigate the anti-fungal activity of Morinda citrifolia fruit extract on Candida albicans. MATERIALS AND METHODS: Juice extract from M. citrifolia fruit was lyophilized and used in anti-fungal testing. Anti-fungal activity of M. citrifolia fruit extract against C. albicans was tested in vitro at various concentrations. The inhibitory effect of M. citrifolia extract on C. albicans was determined by agar culture and applied broth dilution test. RESULTS:M. citrifolia extract at 1000 μg/ml concentration effectively inhibited the growth of C. albicans (16.6 ± 0.3) compared with the positive control - amphotericin B (20.6 ± 0.6). It was found to be a dose-dependent reaction. CONCLUSION:M. citrifolia fruit extract had an anti-fungal effect on C. albicans and the inhibitory effect varied with concentration.
Authors: Luana David do Carmo; Gisele de Fátima Pinheiro Rangel; Liviane Maria Alves Rabelo; Tamiris de Fátima Goebel de Souza; Roberto César Pereira Lima Júnior; Deysi Viviana Tenazoa Wong; Renata Ferreira de Carvalho Leitão; Alfredo Augusto Vasconcelos da Silva; Pedro Jorge Caldas Magalhães; Andréa Santos Costa; Dyély de Carvalho Oliveira Campos; Nylane Maria Nunes de Alencar; Hermógenes David de Oliveira Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2022-07-01 Impact factor: 3.195