Jose P Zevallos1,2, Vlad C Sandulache2, John Hamblin2, Heath D Skinner3, Jennifer Kramer4,5, Christine M Hartman4, Kelsey L Horter2, Syeling Lai6,7, Xiaodong Zhou8, Elizabeth Y Chiao4,5. 1. Otolaryngology/Head and Neck Surgery, Michael E. DeBakey VA Medical Center, Houston, Texas. 2. Bobby R. Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, Texas. 3. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 4. VA Health Services Research and Development Center for Innovations in Quality, Effectiveness, and Safety, Michael E. DeBakey VA Medical Center, Houston, Texas. 5. Department of Medicine, Baylor College of Medicine, Houston, Texas. 6. Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas. 7. Department of Pathology, Michael E. DeBakey VA Medical Center, Houston, Texas. 8. Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas.
Abstract
BACKGROUND: Racial disparities in oropharyngeal squamous cell carcinoma (SCC) have been demonstrated and attributed to differences in human papillomavirus (HPV) status. The purpose of this study was to examine racial disparities in oropharyngeal SCC among veterans. METHODS: Retrospective review of patients with oropharyngeal SCC at a tertiary-care Veterans Affairs (VA) hospital. Adjusted Cox proportional hazards models were conducted to examine the effect of race on oropharyngeal SCC outcomes. RESULTS: Of 158 patients, 126 (79.7%) were white and 32 (20.3%) were African American. No difference in p16 tumor expression was noted between the groups. Five-year disease-free survival (DFS) was 42.6% and 55.1% for African Americans and whites, respectively (p = .372). Five-year overall survival (OS) for African Americans and whites was 54.6% and 51.8%, respectively (p = .768). On multivariate analysis, there was no significant difference in risk of recurrence or death by race. CONCLUSION: Racial disparities are largely ameliorated in patients with oropharyngeal SCC treated within the VA, there were no racial differences in p16 tumor expression, and outcomes remain poor.
BACKGROUND: Racial disparities in oropharyngeal squamous cell carcinoma (SCC) have been demonstrated and attributed to differences in human papillomavirus (HPV) status. The purpose of this study was to examine racial disparities in oropharyngeal SCC among veterans. METHODS: Retrospective review of patients with oropharyngeal SCC at a tertiary-care Veterans Affairs (VA) hospital. Adjusted Cox proportional hazards models were conducted to examine the effect of race on oropharyngeal SCC outcomes. RESULTS: Of 158 patients, 126 (79.7%) were white and 32 (20.3%) were African American. No difference in p16tumor expression was noted between the groups. Five-year disease-free survival (DFS) was 42.6% and 55.1% for African Americans and whites, respectively (p = .372). Five-year overall survival (OS) for African Americans and whites was 54.6% and 51.8%, respectively (p = .768). On multivariate analysis, there was no significant difference in risk of recurrence or death by race. CONCLUSION: Racial disparities are largely ameliorated in patients with oropharyngeal SCC treated within the VA, there were no racial differences in p16tumor expression, and outcomes remain poor.
Authors: Marcus A Florez; Jan O Kemnade; Nan Chen; Wendy Du; Anita L Sabichi; Daniel Y Wang; Quillan Huang; Courtney N Miller-Chism; Aparna Jotwani; Albert C Chen; David Hernandez; Vlad C Sandulache Journal: Cancer Res Commun Date: 2022-07-26
Authors: Peter A Richardson; Sagar Kansara; George G Chen; Anita Sabichi; Andrew G Sikora; Robert B Parke; Donald T Donovan; Elizabeth Chiao; Vlad C Sandulache Journal: Laryngoscope Investig Otolaryngol Date: 2018-08-09
Authors: J O Kemnade; H Elhalawani; P Castro; J Yu; S Lai; M Ittmann; A S R Mohamed; S Y Lai; C D Fuller; A G Sikora; V C Sandulache Journal: Sci Rep Date: 2020-01-14 Impact factor: 4.379
Authors: Siddharth Sheth; Douglas R Farquhar; Nicholas R Lenze; Angela Mazul; Paul Brennan; Devasena Anantharaman; Behnoush Abedi-Ardekani; Jose P Zevallos; D Neil Hayes; F Olshan Journal: Am J Otolaryngol Date: 2020-10-22 Impact factor: 1.808
Authors: Vlad C Sandulache; David C Wilde; Erich M Sturgis; Elizabeth Y Chiao; Andrew G Sikora Journal: Laryngoscope Investig Otolaryngol Date: 2019-10-17