Literature DB >> 24992304

Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation.

J C Bailey1, M Feelisch2, J D Horowitz3, M P Frenneaux4, M Madhani5.   

Abstract

Nitrite has emerged as an important bioactive molecule that can be biotransformed to nitric oxide (NO) related metabolites in normoxia and reduced to NO under hypoxic and acidic conditions to exert vasodilatory effects and confer a variety of other benefits to the cardiovascular system. Abundant research is currently underway to understand the mechanisms involved and define the role of nitrite in health and disease. In this review we discuss the impact of nitrite and dietary nitrate on vascular function and the potential therapeutic role of nitrite in acute heart failure.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Heart failure; Nitrate; Nitric oxide; Nitrite; Vasodilatation

Mesh：

Substances：

Year:  2014        PMID： 24992304     DOI： 10.1016/j.pharmthera.2014.06.009

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  17 in total

1.  Effects of nitrite infusion on skeletal muscle vascular control during exercise in rats with chronic heart failure.

Authors:  Angela A Glean; Scott K Ferguson; Clark T Holdsworth; Trenton D Colburn; Jennifer L Wright; Alex J Fees; Karen S Hageman; David C Poole; Timothy I Musch
Journal:  Am J Physiol Heart Circ Physiol       Date:  2015-09-14       Impact factor: 4.733

2.  Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humans.

Authors:  Maria Ntessalen; Nathan E K Procter; Konstantin Schwarz; Brodie L Loudon; Magdalena Minnion; Bernadette O Fernandez; Vassilios S Vassiliou; David Vauzour; Melanie Madhani; Dumitru Constantin-Teodosiu; John D Horowitz; Martin Feelisch; Dana Dawson; Paul G Crichton; Michael P Frenneaux
Journal:  Am J Clin Nutr       Date:  2020-01-01       Impact factor: 7.045

3.  Effect of nebivolol on renal nitric oxide availability and tubular function in patients with essential hypertension.

Authors:  Frank H Mose; Janni M Jensen; Safa Therwani; Jesper Mortensen; Annebirthe B Hansen; Jesper N Bech; Erling B Pedersen
Journal:  Br J Clin Pharmacol       Date:  2015-06-05       Impact factor: 4.335

Review 4.  Targeting vascular (endothelial) dysfunction.

Authors:  Andreas Daiber; Sebastian Steven; Alina Weber; Vladimir V Shuvaev; Vladimir R Muzykantov; Ismail Laher; Huige Li; Santiago Lamas; Thomas Münzel
Journal:  Br J Pharmacol       Date:  2016-07-04       Impact factor: 8.739

5.  Effect of sodium nitrite on local control of contracting skeletal muscle microvascular oxygen pressure in healthy rats.

Authors:  Trenton D Colburn; Scott K Ferguson; Clark T Holdsworth; Jesse C Craig; Timothy I Musch; David C Poole
Journal:  J Appl Physiol (1985)       Date:  2016-10-27

6.  Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans.

Authors:  Sayqa Arif; Alessandra Borgognone; Erica Lai-Sze Lin; Aine G O'Sullivan; Vishal Sharma; Nigel E Drury; Ashvini Menon; Peter Nightingale; Jorge Mascaro; Robert S Bonser; John D Horowitz; Martin Feelisch; Michael P Frenneaux; Melanie Madhani
Journal:  Br J Pharmacol       Date:  2015-04-29       Impact factor: 8.739

7.  Effects of dietary nitrate on respiratory physiology at high altitude - Results from the Xtreme Alps study.

Authors:  Andrew F Cumpstey; Philip J Hennis; Edward T Gilbert-Kawai; Bernadette O Fernandez; Matthieu Poudevigne; Alexandra Cobb; Paula Meale; Kay Mitchell; Helen Moyses; Helmut Pöhnl; Monty G Mythen; Michael P W Grocott; Martin Feelisch; Daniel S Martin
Journal:  Nitric Oxide       Date:  2017-10-16       Impact factor: 4.898

8.  Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation.

Authors:  Alessandra Borgognone; Eduard Shantsila; Sophie M Worrall; Eakkapote Prompunt; Thomas Loka; Brodie L Loudon; Myriam Chimen; G Ed Rainger; Janet M Lord; Ashley Turner; Peter Nightingale; Martin Feelisch; Paulus Kirchhof; Gregory Y H Lip; Steve P Watson; Michael P Frenneaux; Melanie Madhani
Journal:  Cardiovasc Res       Date:  2018-08-01       Impact factor: 10.787

9.  Nitrite mediated vasorelaxation in human chorionic plate vessels is enhanced by hypoxia and dependent on the NO-sGC-cGMP pathway.

Authors:  Teresa Tropea; Mark Wareing; Susan L Greenwood; Martin Feelisch; Colin P Sibley; Elizabeth C Cottrell
Journal:  Nitric Oxide       Date:  2018-09-01       Impact factor: 4.427

Review 10.  Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm.

Authors:  Brodie L Loudon; Hannah Noordali; Nicholas D Gollop; Michael P Frenneaux; Melanie Madhani
Journal:  Br J Pharmacol       Date:  2016-05-06       Impact factor: 8.739
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