| Literature DB >> 24990848 |
Gilbert T Chua1, Kam Ching Chow2, Jason Chi Chiu So3, Daniel Ka Leung Cheuk4.
Abstract
A 19-month-old Chinese girl presented with pathological fracture of her right distal tibia. Peripheral blood revealed no abnormal cells, electrolytes were normal and bone biopsy at the fracture site only showed small aggregates of unremarkable lymphocytes. A bone marrow study could not provide a definitive diagnosis of acute leukaemia on morphology and immunohistochemistry. A diagnosis of precursor B-cell acute lymphoblastic leukaemia was unequivocally confirmed by a cytogenetic study which showed a hyperdiploid clone with gain of chromosome 4 among other trisomies. 2014 BMJ Publishing Group Ltd.Entities:
Mesh:
Year: 2014 PMID: 24990848 PMCID: PMC4091132 DOI: 10.1136/bcr-2014-204690
Source DB: PubMed Journal: BMJ Case Rep ISSN: 1757-790X