Malleshappa Pavan1. 1. Division of Nephrology, Department of Medicine, Adichunchanagiri Institute of Medical Sciences B. G. Nagara, Karnataka State, India - dr_pavanm@yahoo.co.in.
Abstract
BACKGROUND: One of the main goals in chronic kidney disease (CKD) patients is to diminish the accumulation of uremic toxins and to slow the progression of renal failure. We investigated whether prebiotic and probiotic supplementation along with low protein diet retards the progression of CKD. METHODS: This is a 12-month prospective observation study with a randomized control and open-label design. A total of 24 stable CKD stage III to V patients, who are not on renal replacement therapy, were enrolled in this study. Patients were randomly assigned to 2 groups: low protein diet + prebiotic + probiotic supplementation (N.=12), receiving 3 tablets of prebiotic + probiotic supplementation daily for 6 months, and the control group receiving low protein diet only (N.=12). We examined the effects of prebiotic and probiotic supplementation on estimated glomerular filtration rate (eGFR) in CKD. RESULTS: The declining GFR during prebiotic and probiotic supplementation were significantly lower (-11.6±8.6 vs. -3.4±4.6 mL/min per 1.73 m2 per year, 95% CI -6.45 - -9.86, P<0.001) than those with low protein diet alone. CONCLUSIONS:Prebiotic and probiotic supplementation along with low protein diet delayed the progression of CKD.
RCT Entities:
BACKGROUND: One of the main goals in chronic kidney disease (CKD) patients is to diminish the accumulation of uremic toxins and to slow the progression of renal failure. We investigated whether prebiotic and probiotic supplementation along with low protein diet retards the progression of CKD. METHODS: This is a 12-month prospective observation study with a randomized control and open-label design. A total of 24 stable CKD stage III to V patients, who are not on renal replacement therapy, were enrolled in this study. Patients were randomly assigned to 2 groups: low protein diet + prebiotic + probiotic supplementation (N.=12), receiving 3 tablets of prebiotic + probiotic supplementation daily for 6 months, and the control group receiving low protein diet only (N.=12). We examined the effects of prebiotic and probiotic supplementation on estimated glomerular filtration rate (eGFR) in CKD. RESULTS: The declining GFR during prebiotic and probiotic supplementation were significantly lower (-11.6±8.6 vs. -3.4±4.6 mL/min per 1.73 m2 per year, 95% CI -6.45 - -9.86, P<0.001) than those with low protein diet alone. CONCLUSIONS: Prebiotic and probiotic supplementation along with low protein diet delayed the progression of CKD.
Authors: Mehmet Kanbay; Emine M Onal; Baris Afsar; Tuncay Dagel; Aslihan Yerlikaya; Adrian Covic; Nosratola D Vaziri Journal: Int Urol Nephrol Date: 2018-05-04 Impact factor: 2.370
Authors: Raymond Vanholder; Steven Van Laecke; Griet Glorieux; Francis Verbeke; Esmeralda Castillo-Rodriguez; Alberto Ortiz Journal: Toxins (Basel) Date: 2018-06-12 Impact factor: 4.546
Authors: Carmela Cosola; Maria Teresa Rocchetti; Ighli di Bari; Paola Maria Acquaviva; Valentina Maranzano; Simone Corciulo; Agostino Di Ciaula; Domenica Maria Di Palo; Flavia Maria La Forgia; Sergio Fontana; Maria De Angelis; Piero Portincasa; Loreto Gesualdo Journal: Toxins (Basel) Date: 2021-05-05 Impact factor: 4.546