| Literature DB >> 24990263 |
Danielle J Vugts1, Guus A M S van Dongen2.
Abstract
(89)Zr-immuno-PET is an attractive option for the in vivo evaluation of monoclonal antibodies (mAbs). For the coupling of (89)Zr to monoclonal antibodies several conjugation strategies are available all using desferrioxamine as chelate. Here we discuss the production of (89)Zr, the available methods for coupling of (89)Zr via desferrioxamine to mAbs, and the evaluation of (89)Zr-mAb conjugates in preclinical and clinical studies.:Entities:
Year: 2011 PMID： 24990263 DOI： 10.1016/j.ddtec.2011.12.004
Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749