Literature DB >> 24988901

No correlation between serotonin and its metabolite 5-HIAA in the cerebrospinal fluid and [(11) C]AZ10419369 binding measured with PET in healthy volunteers.

Mikael Tiger1, Per Svenningsson, Magdalena Nord, Sandra Jabre, Christer Halldin, Johan Lundberg.   

Abstract

[(11) C]AZ10419369 is sensitive to pharmacologically enhanced endogenous serotonin levels. Twelve healthy volunteers underwent [(11) C]AZ10419369 PET and lumbar puncture. There were no correlations between [(11) C]AZ10419369 binding and concentrations of serotonin and its metabolite 5-HIAA in cerebrospinal fluid, suggesting that [(11) C]AZ10419369 brain binding does not reflect baseline serotonin levels in cerebrospinal fluid.
© 2014 Wiley Periodicals, Inc.

Entities:  

Keywords:  5-HT1B receptors; autoreceptor; displacement; sensitivity

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Year:  2014        PMID： 24988901     DOI： 10.1002/syn.21761

Source DB:  PubMed          Journal:  Synapse        ISSN： 0887-4476            Impact factor:   2.562


  3 in total

Review 1.  PET tracers for serotonin receptors and their applications.

Authors:  J S Dileep Kumar; J John Mann
Journal:  Cent Nerv Syst Agents Med Chem       Date:  2014

2.  A randomized placebo-controlled PET study of ketamine´s effect on serotonin1B receptor binding in patients with SSRI-resistant depression.

Authors:  Mikael Tiger; Emma R Veldman; Carl-Johan Ekman; Christer Halldin; Per Svenningsson; Johan Lundberg
Journal:  Transl Psychiatry       Date:  2020-06-01       Impact factor: 6.222

3.  Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography.

Authors:  Emma R Veldman; Andrea Varrone; Katarina Varnäs; Marie M Svedberg; Zsolt Cselényi; Mikael Tiger; Balázs Gulyás; Christer Halldin; Johan Lundberg
Journal:  J Cereb Blood Flow Metab       Date:  2021-10-13       Impact factor: 6.960
  3 in total

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