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Literature DB >> 24988456

Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission.

Abstract

Mitochondrial DNA diseases are relatively common, sometimes devastating, and transmitted exclusively through the egg to children of carrier mothers. A study in Cell by Wang et al. (2014) adds the exciting possibility of a new therapy for preventing mitochondrial disease transmission predicated on the use of polar body genomes in mice.

Entities: Disease Gene Species

Mesh：

Year: 2014 PMID： 24988456 PMCID： PMC4095871 DOI： 10.1016/j.cmet.2014.06.012

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

8 in total

Review 1. Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.

Authors: Douglas C Wallace; Dimitra Chalkia
Journal: Cold Spring Harb Perspect Biol Date: 2013-11-01 Impact factor: 10.005

2. Reproductive medicine: The power of three.

Authors: Ewen Callaway
Journal: Nature Date: 2014-05-22 Impact factor: 49.962

3. Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck.

Authors: Hyo-Sang Lee; Hong Ma; Rita Cervera Juanes; Masahito Tachibana; Michelle Sparman; Joy Woodward; Cathy Ramsey; Jing Xu; Eun-Ju Kang; Paula Amato; Georg Mair; Ralf Steinborn; Shoukhrat Mitalipov
Journal: Cell Rep Date: 2012-05-31 Impact factor: 9.423

4. Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease.

Authors: Lyndsey Craven; Helen A Tuppen; Gareth D Greggains; Stephen J Harbottle; Julie L Murphy; Lynsey M Cree; Alison P Murdoch; Patrick F Chinnery; Robert W Taylor; Robert N Lightowlers; Mary Herbert; Douglass M Turnbull
Journal: Nature Date: 2010-04-14 Impact factor: 49.962

5. Preventing the transmission of pathogenic mitochondrial DNA mutations: Can we achieve long-term benefits from germ-line gene transfer?

Authors: David C Samuels; Passorn Wonnapinij; Patrick F Chinnery
Journal: Hum Reprod Date: 2013-01-07 Impact factor: 6.918

6. Mitochondrial gene replacement in primate offspring and embryonic stem cells.

Authors: Masahito Tachibana; Michelle Sparman; Hathaitip Sritanaudomchai; Hong Ma; Lisa Clepper; Joy Woodward; Ying Li; Cathy Ramsey; Olena Kolotushkina; Shoukhrat Mitalipov
Journal: Nature Date: 2009-08-26 Impact factor: 49.962

7. Towards germline gene therapy of inherited mitochondrial diseases.

Authors: Masahito Tachibana; Paula Amato; Michelle Sparman; Joy Woodward; Dario Melguizo Sanchis; Hong Ma; Nuria Marti Gutierrez; Rebecca Tippner-Hedges; Eunju Kang; Hyo-Sang Lee; Cathy Ramsey; Keith Masterson; David Battaglia; David Lee; Diana Wu; Jeffrey Jensen; Phillip Patton; Sumita Gokhale; Richard Stouffer; Shoukhrat Mitalipov
Journal: Nature Date: 2012-10-24 Impact factor: 49.962

8. Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.

Authors: Jaime M Ross; James B Stewart; Erik Hagström; Stefan Brené; Arnaud Mourier; Giuseppe Coppotelli; Christoph Freyer; Marie Lagouge; Barry J Hoffer; Lars Olson; Nils-Göran Larsson
Journal: Nature Date: 2013-08-21 Impact factor: 49.962

8 in total

5 in total

Review 1. Modifying the Mitochondrial Genome.

Authors: Alexander N Patananan; Ting-Hsiang Wu; Pei-Yu Chiou; Michael A Teitell
Journal: Cell Metab Date: 2016-05-10 Impact factor: 27.287