Negar Tabatabaei1, Yves Giguère2, Jean-Claude Forest2, Celia J Rodd3, Richard Kremer4, Hope A Weiler5. 1. School of Dietetics and Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada. 2. Centre Hospitalier Universitaire de Québec Research Centre et Faculté de médecine, Université Laval, Québec City, Quebec, Canada. 3. Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada. 4. Department of Medicine, Calcium Research Laboratory, McGill University, Montreal, Quebec, Canada. 5. School of Dietetics and Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada. Electronic address: hope.weiler@mcgill.ca.
Abstract
OBJECTIVE: The purpose of this study was to investigate circulating concentrations of osteocalcin, a bone-derived protein, while accounting for 25-hydroxyvitamin D (25(OH)D) throughout pregnancy, and whether early gestation concentrations and changes in osteocalcin predict the subsequent diagnosis of gestational diabetes mellitus (GDM). METHODS: This was a nested case-control study involving 48 GDM and 48 control pregnant Caucasian women (matched for age, season of conception, pre-pregnancy body mass index and pregnancy length). Maternal serum osteocalcin was measured by enzyme-linked immunosorbent assay and 25(OH)D by chemiluminescence throughout pregnancy (11-13 weeks, 24-28 weeks and predelivery). Differences between groups were compared by mixed model analysis of variance. Predictors of diagnosis of GDM were explored using generalized estimating equation models. Neonatal general health outcomes were also compared between groups. RESULTS: Serum osteocalcin was higher across pregnancy (p=0.006) in women with GDM vs. controls, whereas serum 25(OH)D was not different (p=0.80). Both biomarkers increased with time across pregnancy (p<0.0001). However, serum osteocalcin during early pregnancy and changes in its concentration from early to mid gestation did not predict the development of GDM. There were no significant differences in anthropometry and APGAR (appearance, pulse, grimace, activity, respiration) scores in neonates of controls and cases. CONCLUSIONS: Serum osteocalcin is elevated in Caucasian women with GDM throughout pregnancy, but was not predictive of the onset of GDM. Larger trials evaluating the role of osteocalcin and the development of GDM appear warranted.
OBJECTIVE: The purpose of this study was to investigate circulating concentrations of osteocalcin, a bone-derived protein, while accounting for 25-hydroxyvitamin D (25(OH)D) throughout pregnancy, and whether early gestation concentrations and changes in osteocalcin predict the subsequent diagnosis of gestational diabetes mellitus (GDM). METHODS: This was a nested case-control study involving 48 GDM and 48 control pregnant Caucasian women (matched for age, season of conception, pre-pregnancy body mass index and pregnancy length). Maternal serum osteocalcin was measured by enzyme-linked immunosorbent assay and 25(OH)D by chemiluminescence throughout pregnancy (11-13 weeks, 24-28 weeks and predelivery). Differences between groups were compared by mixed model analysis of variance. Predictors of diagnosis of GDM were explored using generalized estimating equation models. Neonatal general health outcomes were also compared between groups. RESULTS: Serum osteocalcin was higher across pregnancy (p=0.006) in women with GDM vs. controls, whereas serum 25(OH)D was not different (p=0.80). Both biomarkers increased with time across pregnancy (p<0.0001). However, serum osteocalcin during early pregnancy and changes in its concentration from early to mid gestation did not predict the development of GDM. There were no significant differences in anthropometry and APGAR (appearance, pulse, grimace, activity, respiration) scores in neonates of controls and cases. CONCLUSIONS: Serum osteocalcin is elevated in Caucasian women with GDM throughout pregnancy, but was not predictive of the onset of GDM. Larger trials evaluating the role of osteocalcin and the development of GDM appear warranted.
Authors: R Saucedo; G Rico; G Vega; L Basurto; L Cordova; R Galvan; M Hernandez; E Puello; A Zarate Journal: J Endocrinol Invest Date: 2014-12-06 Impact factor: 4.256
Authors: Raigam J Martinez-Portilla; Jose R Villafan-Bernal; Diana L Lip-Sosa; Eva Meler; Jordi Clotet; Francisco J Serna-Vela; Sergio Velazquez-Garcia; Leopoldo C Serrano-Diaz; Francesc Figueras Journal: J Diabetes Res Date: 2018-12-30 Impact factor: 4.011