PURPOSE: This study aimed to explore differences in physical activity and fitness between women with metastatic breast cancer compared to healthy controls and factors associated with their physical activity levels. METHODS: Seventy-one women with metastatic breast cancer, aged (mean (SD)) 57.7 (9.5) and 2.9 (3.1) years after the onset of metastatic disease, and 71 healthy controls aged 55.0 (9.4) years participated. Of those with metastatic disease, 27% had bone-only metastases, 35% visceral-only metastases and 38% bone and visceral metastases. Patient-reported outcomes and physical measures of muscle strength and aerobic fitness assessments were obtained. Participants wore a SenseWear® physical activity monitor over 7 days, and the average steps/day and the time spent in moderate-to-vigorous intensity physical activity were determined. RESULTS: Women with metastases were significantly (i) less aerobically fit than the control group (25.3 (5.4) vs. 31.9 (6.1) mL • kg(-1) • min(-1); P < 0.001); (ii) weaker (e.g. lower limb strength for the metastatic and control groups was 53.5 (23.7) vs. 76.0 (27.4) kg, respectively; P < 0.001); (iii) less active, with the metastatic group attaining only 56% of the mean daily step counts of the healthy women; and (iv) more symptomatic, reporting higher levels of fatigue and dyspnoea (P < 0.001). CONCLUSION: Women living in the community with metastatic breast cancer possessed lower aerobic fitness, reduced muscular strength and less daily physical activity compared to healthy counterparts. They also experienced poorer functioning and higher symptom burden. IMPLICATIONS FOR CANCER SURVIVORS: Women living with metastatic breast cancer may benefit from a physical activity programme to address their physical impairments.
PURPOSE: This study aimed to explore differences in physical activity and fitness between women with metastatic breast cancer compared to healthy controls and factors associated with their physical activity levels. METHODS: Seventy-one women with metastatic breast cancer, aged (mean (SD)) 57.7 (9.5) and 2.9 (3.1) years after the onset of metastatic disease, and 71 healthy controls aged 55.0 (9.4) years participated. Of those with metastatic disease, 27% had bone-only metastases, 35% visceral-only metastases and 38% bone and visceral metastases. Patient-reported outcomes and physical measures of muscle strength and aerobic fitness assessments were obtained. Participants wore a SenseWear® physical activity monitor over 7 days, and the average steps/day and the time spent in moderate-to-vigorous intensity physical activity were determined. RESULTS:Women with metastases were significantly (i) less aerobically fit than the control group (25.3 (5.4) vs. 31.9 (6.1) mL • kg(-1) • min(-1); P < 0.001); (ii) weaker (e.g. lower limb strength for the metastatic and control groups was 53.5 (23.7) vs. 76.0 (27.4) kg, respectively; P < 0.001); (iii) less active, with the metastatic group attaining only 56% of the mean daily step counts of the healthy women; and (iv) more symptomatic, reporting higher levels of fatigue and dyspnoea (P < 0.001). CONCLUSION:Women living in the community with metastatic breast cancer possessed lower aerobic fitness, reduced muscular strength and less daily physical activity compared to healthy counterparts. They also experienced poorer functioning and higher symptom burden. IMPLICATIONS FOR CANCER SURVIVORS: Women living with metastatic breast cancer may benefit from a physical activity programme to address their physical impairments.
Authors: F Efficace; L Biganzoli; M Piccart; C Coens; K Van Steen; T Cufer; R E Coleman; H A Calvert; T Gamucci; C Twelves; P Fargeot; A Bottomley Journal: Eur J Cancer Date: 2004-05 Impact factor: 9.162
Authors: William L Haskell; I-Min Lee; Russell R Pate; Kenneth E Powell; Steven N Blair; Barry A Franklin; Caroline A Macera; Gregory W Heath; Paul D Thompson; Adrian Bauman Journal: Med Sci Sports Exerc Date: 2007-08 Impact factor: 5.411
Authors: Jane Louise Phillips; Lawrence Lam; Tim Luckett; Meera Agar; David Currow Journal: J Pain Symptom Manage Date: 2013-10-02 Impact factor: 3.612
Authors: Sandahl H Nelson; Lauren S Weiner; Loki Natarajan; Barbara A Parker; Ruth E Patterson; Sheri J Hartman Journal: Transl Behav Med Date: 2020-10-08 Impact factor: 3.046
Authors: Melisa L Wong; Ying Shi; Alexander K Smith; Christine Miaskowski; W John Boscardin; Harvey Jay Cohen; Vivian Lam; Melissa Mazor; Lia Metzger; Carolyn J Presley; Grant R Williams; Kah Poh Loh; Carling J Ursem; Terence W Friedlander; Collin M Blakely; Matthew A Gubens; Gregory Allen; Dianne Shumay; Louise C Walter Journal: J Am Geriatr Soc Date: 2021-10-05 Impact factor: 5.562
Authors: Timothy J Williamson; Susan M Love; Jessica N Clague DeHart; Alexandra Jorge-Miller; Leah Eshraghi; Heather Cooper Ortner; Annette L Stanton Journal: Breast Cancer Res Treat Date: 2018-05-16 Impact factor: 4.872
Authors: Patricia Sheean; Lauren Matthews; Alexis Visotcky; Anjishnu Banerjee; Andrea Moosreiner; Kimberly Kelley; Christopher R Chitambar; Paula E Papanek; Melinda Stolley Journal: Breast Cancer Res Treat Date: 2021-03-19 Impact factor: 4.624
Authors: Anne-Sophie Mazzoni; Karin Nordin; Sveinung Berntsen; Ingrid Demmelmaier; Helena Igelström Journal: BMC Sports Sci Med Rehabil Date: 2017-03-31