K S Sahana1, R Sujatha. 1. Department of Pediatrics, Sapthagiri Institute of Medical Sciences and Research Center, Bangalore, India, dr_sahana2003@yahoo.co.in.
Abstract
OBJECTIVE: To study the clinical profile of dengue fever and its outcome in children with application of revised WHO classification and to identify risk factors for severe dengue. METHODS: This study was a prospective observational study of children diagnosed with dengue from July 2012 through February 2013 at a tertiary care hospital in Bangalore, Karnataka (South India). RESULTS: Eighty one children including 55(67.9 %) boys and 26(32.1 %) girls were diagnosed with dengue. Mean age of presentation was 8 y. Vomiting (60.5 %), pain abdomen (32 %), headache (30.9 %), myalgia (23.5 %) and bleeding manifestations (16 %) were the common presenting complaints. Facial puffiness (63 %), hepatomegaly (51.9 %), ascites (48.1 %), pleural effusion (39.5 %) and petechiae (14.8 %) were noted during examination. Dengue NS1 antigen, IgM, IgG were positive in 66.7 %, 29.6 % and 18.5 % of cases respectively. Investigations showed hemoconcentration in 72.8 %, leucopenia (34.5 %), thrombocytopenia (82.7 %), abnormal liver function test (LFT) (33.3 %). USG abdomen was suggestive of dengue in 66.7 % and gall bladder edema was noted in 53.1 %. Two patients died out of the total 81 patients with mortality rate of 2.5 %. Number of cases classified as Dengue without warning signs (D), Dengue with warning signs (DW) and Severe Dengue (SD) were 48.1 %, 27.2 % and 24.7 % respectively. CONCLUSIONS: Children between 5 and 15 y were most affected by dengue fever. Pain abdomen and vomiting were most common presenting symptoms. Ascites, plerural effusion, hepatomegaly, gall bladder wall thickening and abnormal LFT were found significantly high in severe dengue cases.
OBJECTIVE: To study the clinical profile of dengue fever and its outcome in children with application of revised WHO classification and to identify risk factors for severe dengue. METHODS: This study was a prospective observational study of children diagnosed with dengue from July 2012 through February 2013 at a tertiary care hospital in Bangalore, Karnataka (South India). RESULTS: Eighty one children including 55(67.9 %) boys and 26(32.1 %) girls were diagnosed with dengue. Mean age of presentation was 8 y. Vomiting (60.5 %), pain abdomen (32 %), headache (30.9 %), myalgia (23.5 %) and bleeding manifestations (16 %) were the common presenting complaints. Facial puffiness (63 %), hepatomegaly (51.9 %), ascites (48.1 %), pleural effusion (39.5 %) and petechiae (14.8 %) were noted during examination. Dengue NS1 antigen, IgM, IgG were positive in 66.7 %, 29.6 % and 18.5 % of cases respectively. Investigations showed hemoconcentration in 72.8 %, leucopenia (34.5 %), thrombocytopenia (82.7 %), abnormal liver function test (LFT) (33.3 %). USG abdomen was suggestive of dengue in 66.7 % and gall bladder edema was noted in 53.1 %. Two patients died out of the total 81 patients with mortality rate of 2.5 %. Number of cases classified as Dengue without warning signs (D), Dengue with warning signs (DW) and Severe Dengue (SD) were 48.1 %, 27.2 % and 24.7 % respectively. CONCLUSIONS:Children between 5 and 15 y were most affected by dengue fever. Pain abdomen and vomiting were most common presenting symptoms. Ascites, plerural effusion, hepatomegaly, gall bladder wall thickening and abnormal LFT were found significantly high in severe dengue cases.
Authors: Cristiane N Soares; Mauro J Cabral-Castro; José M Peralta; Marcos R G de Freitas; Mariano Zalis; Marzia Puccioni-Sohler Journal: J Neurol Sci Date: 2011-02-02 Impact factor: 3.181
Authors: Maria G Guzman; Thomas Jaenisch; Roger Gaczkowski; Vo Thi Ty Hang; Shamala Devi Sekaran; Axel Kroeger; Susana Vazquez; Didye Ruiz; Eric Martinez; Juan C Mercado; Angel Balmaseda; Eva Harris; Efren Dimano; Prisca Susan A Leano; Sutee Yoksan; Elci Villegas; Herminia Benduzu; Iris Villalobos; Jeremy Farrar; Cameron P Simmons Journal: PLoS Negl Trop Dis Date: 2010-08-31
Authors: Federico Narvaez; Gamaliel Gutierrez; Maria Angeles Pérez; Douglas Elizondo; Andrea Nuñez; Angel Balmaseda; Eva Harris Journal: PLoS Negl Trop Dis Date: 2011-11-08
Authors: Moustafa A Hegazi; Marwan A Bakarman; Turki S Alahmadi; Nadeem S Butt; Ahmed M Alqahtani; Badr S Aljedaani; Abdulrahman H Almajnuni Journal: Am J Trop Med Hyg Date: 2020-03 Impact factor: 2.345