Literature DB >> 2498571

[Results of clinical trials with the gluconeogenesis inhibitor 2-(3-methylcinnamylhydrazono)-propionate (MCHP)].

R Paschke1, U Schwedes, H Kühnle, J Peter, R Schmeidl, K H Usadel.   

Abstract

Many compounds which directly or indirectly inhibit gluconeogenesis have been described. Some of them showed hypoglycemic action in animal experiments. 2-(3-Methylcinnamylhydrazono)-Propionat (MCHP) a derivative of hydrazine demonstrated marked hypoglycemic action in animal experiments. Nontheless the administration of MCHP to type II diabetic patients showed no hypoglycemic action. Clinical or biochemical sideeffects could not be observed.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2498571     DOI： 10.1007/bf01725138

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  19 in total

1.  The influence of some antidepressives of the hydrazine type on the glucose metabolism in depressed patients.

Authors:  H van PRAAG; B LEIJNSE
Journal:  Clin Chim Acta       Date:  1963-05       Impact factor: 3.786

2.  Effect of the oral hypoglycemic agent, pirogliride, on gluconeogenesis.

Authors:  G F Tutwiler; H J Brentzel
Journal:  Biochem Pharmacol       Date:  1980-05-15       Impact factor: 5.858

3.  Hydrazonopropionic acids, a new class of non-hormonal hypoglycaemic compounds.

Authors:  R Haeckel; M Oellerich
Journal:  Biochem Soc Trans       Date:  1979-08       Impact factor: 5.407

4.  Effects of two new alpha-glucosidase inhibitors on glycemic control in patients with insulin-dependent diabetes mellitus.

Authors:  G Dimitriadis; S Raptis; A Raptis; E Hatziagelaki; A Mitrakou; P Halvatsiotis; S Ladas; I Hillebrand
Journal:  Klin Wochenschr       Date:  1986-05-02

5.  Pharmacologic profile of methyl 2-tetradecylglycidate (McN-3716)--an orally effective hypoglycemic agent.

Authors:  G F Tutwiler; T Kirsch; R J Mohrbacher; W Ho
Journal:  Metabolism       Date:  1978-10       Impact factor: 8.694

6.  Relation of oxidation of long-chain fatty acids to gluconeogenesis in the perfused liver of the guinea pig: effect of 2-tetradecylglycidic acid (McN-3802).

Authors:  G F Tutwiler; H J Brentzel
Journal:  Eur J Biochem       Date:  1982-06

7.  Hydrazonopropionic acids, a new class of hypoglycemic substances. 5. Inhibition of hepatic gluconeogenesis by 2-(3-methylcinnamyl-hydrazono)-propionate in the rat and guinea pig.

Authors:  R Haeckel; M Oellerich; G Schumann; M Beneking
Journal:  Horm Metab Res       Date:  1985-03       Impact factor: 2.936

8.  Studies on the mechanism of action of the hypoglycemic agent, 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304).

Authors:  I V Deaciuc; H F Kühnle; K M Strauss; F H Schmidt
Journal:  Biochem Pharmacol       Date:  1983-11-15       Impact factor: 5.858

9.  Phenylalkyloxirane carboxylic acids, a new class of hypoglycaemic substances: hypoglycaemic and hypoketonaemic effects of sodium 2-[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (B 807-27) in fasted animals.

Authors:  H P Wolf; K Eistetter; G Ludwig
Journal:  Diabetologia       Date:  1982-06       Impact factor: 10.122

10.  Inhibition of gluconeogenesis in isolated rat liver cells by methylenecyclopropylpyruvate (ketohypoglycin).

Authors:  E A Kean; C I Pogson
Journal:  Biochem J       Date:  1979-09-15       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.