Literature DB >> 24985331

How could SNARE proteins open a fusion pore?

Qinghua Fang1, Manfred Lindau2.   

Abstract

The SNARE (Soluble NSF Attachment protein REceptor) complex, which in mammalian neurosecretory cells is composed of the proteins synaptobrevin 2 (also called VAMP2), syntaxin, and SNAP-25, plays a key role in vesicle fusion. In this review, we discuss the hypothesis that, in neurosecretory cells, fusion pore formation is directly accomplished by a conformational change in the SNARE complex via movement of the transmembrane domains. ©2014 Int. Union Physiol. Sci./Am. Physiol. Soc.

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Year:  2014        PMID： 24985331      PMCID： PMC4103061          DOI： 10.1152/physiol.00026.2013

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  71 in total

1.  Multiple kinetic components of exocytosis distinguished by neurotoxin sensitivity.

Authors:  T Xu; T Binz; H Niemann; E Neher
Journal:  Nat Neurosci       Date:  1998-07       Impact factor: 24.884

2.  Peptide mimics of SNARE transmembrane segments drive membrane fusion depending on their conformational plasticity.

Authors:  D Langosch; J M Crane; B Brosig; A Hellwig; L K Tamm; J Reed
Journal:  J Mol Biol       Date:  2001-08-24       Impact factor: 5.469

3.  Complexins regulate a late step in Ca2+-dependent neurotransmitter release.

Authors:  K Reim; M Mansour; F Varoqueaux; H T McMahon; T C Südhof; N Brose; C Rosenmund
Journal:  Cell       Date:  2001-01-12       Impact factor: 41.582

4.  Role of the synaptobrevin C terminus in fusion pore formation.

Authors:  Annita N Ngatchou; Kassandra Kisler; Qinghua Fang; Alexander M Walter; Ying Zhao; Dieter Bruns; Jakob B Sørensen; Manfred Lindau
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-11       Impact factor: 11.205

5.  Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles.

Authors:  Jakob B Sørensen; Katrin Wiederhold; Emil M Müller; Ira Milosevic; Gábor Nagy; Bert L de Groot; Helmut Grubmüller; Dirk Fasshauer
Journal:  EMBO J       Date:  2006-02-23       Impact factor: 11.598

Review 6.  The role of transmembrane domains in membrane fusion.

Authors:  D Langosch; M Hofmann; C Ungermann
Journal:  Cell Mol Life Sci       Date:  2007-04       Impact factor: 9.261

7.  Caught in the act: visualization of SNARE-mediated fusion events in molecular detail.

Authors:  Herre Jelger Risselada; Carsten Kutzner; Helmut Grubmüller
Journal:  Chembiochem       Date:  2011-03-23       Impact factor: 3.164

Review 8.  SNARE complexes and neuroexocytosis: how many, how close?

Authors:  Cesare Montecucco; Giampietro Schiavo; Sergio Pantano
Journal:  Trends Biochem Sci       Date:  2005-07       Impact factor: 13.807

9.  Complexin cross-links prefusion SNAREs into a zigzag array.

Authors:  Daniel Kümmel; Shyam S Krishnakumar; Daniel T Radoff; Feng Li; Claudio G Giraudo; Frederic Pincet; James E Rothman; Karin M Reinisch
Journal:  Nat Struct Mol Biol       Date:  2011-07-24       Impact factor: 15.369

Review 10.  Mechanism of action of tetanus and botulinum neurotoxins.

Authors:  C Montecucco; G Schiavo
Journal:  Mol Microbiol       Date:  1994-07       Impact factor: 3.501
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  26 in total

1.  Function Suggests Nano-Structure: Quantitative Structural Support for SNARE-Mediated Pore Formation.

Authors:  Ilan Hammel; Isaac Meilijson
Journal:  Neurotox Res       Date:  2015-09-25       Impact factor: 3.911

Review 2.  Energetics, kinetics, and pathway of SNARE folding and assembly revealed by optical tweezers.

Authors:  Yongli Zhang
Journal:  Protein Sci       Date:  2017-03-08       Impact factor: 6.725

3.  The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores.

Authors:  María F Quevedo; Ornella Lucchesi; Matías A Bustos; Cristian A Pocognoni; Paola X De la Iglesia; Claudia N Tomes
Journal:  J Biol Chem       Date:  2016-09-09       Impact factor: 5.157

4.  Cell biology: Bulky tether proteins aid membrane fusion.

Authors:  Anne Spang
Journal:  Nature       Date:  2017-11-01       Impact factor: 49.962

5.  Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming.

Authors:  Joana S Martins; Sébastien Houy; Cordelia Imig; Bassam Tawfik; Paulo S Pinheiro; Sonja M Wojcik; Nils Brose; Benjamin H Cooper; Jakob Balslev Sørensen
Journal:  Elife       Date:  2021-03-22       Impact factor: 8.140

Review 6.  Therapeutic targeting of neutrophil exocytosis.

Authors:  Sergio D Catz; Kenneth R McLeish
Journal:  J Leukoc Biol       Date:  2020-01-28       Impact factor: 4.962

7.  Genome-wide translation control analysis of developing human neurons.

Authors:  Érico Moreto Lins; Natássia Cristina Martins Oliveira; Osvaldo Reis; Adriano Ferrasa; Roberto Herai; Alysson R Muotri; Katlin Brauer Massirer; Mário Henrique Bengtson
Journal:  Mol Brain       Date:  2022-06-15       Impact factor: 4.399

Review 8.  Exocytosis Proteins: Typical and Atypical Mechanisms of Action in Skeletal Muscle.

Authors:  Jinhee Hwang; Debbie C Thurmond
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-14       Impact factor: 6.055

9.  Exocytotic fusion pores are composed of both lipids and proteins.

Authors:  Huan Bao; Marcel Goldschen-Ohm; Pia Jeggle; Baron Chanda; J Michael Edwardson; Edwin R Chapman
Journal:  Nat Struct Mol Biol       Date:  2015-12-14       Impact factor: 15.369

10.  Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

Authors:  Alexander M Walter; Rainer Müller; Bassam Tawfik; Keimpe Db Wierda; Paulo S Pinheiro; André Nadler; Anthony W McCarthy; Iwona Ziomkiewicz; Martin Kruse; Gregor Reither; Jens Rettig; Martin Lehmann; Volker Haucke; Bertil Hille; Carsten Schultz; Jakob Balslev Sørensen
Journal:  Elife       Date:  2017-10-25       Impact factor: 8.140
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