BACKGROUND: Alcohol dependence (AD) is one of the major elements that significantly influence drinking pattern that provoke the alcohol-induced organ damage. The structural and neurophysiologic abnormalities in the frontal lobes of chronic alcoholics were revealed by magnetic resonance imaging scans. It is well known that candidate genes involved in dopaminergic pathway are of immense interest to the researchers engaged in a wide range of addictive disorders. Dopaminergic pathway gene polymorphisms are being extensively studied with respect to addictive and behavioral disorders. METHODS: From the broad literature available, the current review summarizes the specific polymorphisms of dopaminergic genes that play a role in alcohol dependence. RESULTS: No evidence indicating any strong association between AD and polymorphisms of dopamine pathway genes has emerged from the literature. DISCUSSION: Further studies are warranted, considering a range of alcohol-related traits to determine the genes that influence alcohol dependence.
BACKGROUND:Alcohol dependence (AD) is one of the major elements that significantly influence drinking pattern that provoke the alcohol-induced organ damage. The structural and neurophysiologic abnormalities in the frontal lobes of chronic alcoholics were revealed by magnetic resonance imaging scans. It is well known that candidate genes involved in dopaminergic pathway are of immense interest to the researchers engaged in a wide range of addictive disorders. Dopaminergic pathway gene polymorphisms are being extensively studied with respect to addictive and behavioral disorders. METHODS: From the broad literature available, the current review summarizes the specific polymorphisms of dopaminergic genes that play a role in alcohol dependence. RESULTS: No evidence indicating any strong association between AD and polymorphisms of dopamine pathway genes has emerged from the literature. DISCUSSION: Further studies are warranted, considering a range of alcohol-related traits to determine the genes that influence alcohol dependence.
Authors: R L Bell; S Hauser; Z A Rodd; T Liang; Y Sari; J McClintick; S Rahman; E A Engleman Journal: Int Rev Neurobiol Date: 2016-03-21 Impact factor: 3.230
Authors: Chun Il Park; Hae Won Kim; Syung Shick Hwang; Jee In Kang; Se Joo Kim Journal: Eur Arch Psychiatry Clin Neurosci Date: 2019-09-26 Impact factor: 5.270
Authors: Olga Yu Fedorenko; Ekaterina V Mikhalitskaya; Valentina A Toshchakova; Anton J M Loonen; Nikolay A Bokhan; Svetlana A Ivanova Journal: Genes (Basel) Date: 2021-10-19 Impact factor: 4.096