Literature DB >> 2498254

Multi-step carcinogenesis model for adult T-cell leukemia.

T Okamoto1, Y Ohno, S Tsugane, S Watanabe, M Shimoyama, K Tajima, M Miwa, K Shimotohno.   

Abstract

The age-specific occurrence of adult T-cell leukemia (ATL) was analyzed using 357 cases collected during nationwide surveys carried out between 1982 and 1985 in Japan. A simple Weibull distribution function fitted well as a model. The mode of ATL onset was log-linear in this model and the curves for males and females overlapped completely. The presence of age-dependent accumulation of leukemogenic events within human T-cell leukemia virus type 1-immortalized T cells was suggested prior to the development of ATL, and the approximate number of independent leukemogenic events in ATL is estimated to be five. This stochastic analysis supported a multi-step carcinogenesis as an appropriate model for ATL.

Entities:  

Mesh：

Year:  1989        PMID： 2498254      PMCID： PMC5917708          DOI： 10.1111/j.1349-7006.1989.tb02289.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


adult T‐cell leukemia human T‐cell leukemia virus type 1
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