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Literature DB >> 2498243

Mutations of N-ras oncogene in myelodysplastic syndromes and leukemias detected by polymerase chain reaction.

Abstract

By using polymerase chain reaction and differential hybridization, point mutations of N-ras oncogene were investigated among 43 patients with hematopoietic malignancies. Six cases were revealed to carry mutational N-ras oncogenes. One case with acute myelocytic leukemia was found to carry a mutation at codon 13, although this case was in complete remission.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
DNA Probes
DNA, Neoplasm

Year: 1989 PMID： 2498243 PMCID： PMC5917694 DOI： 10.1111/j.1349-7006.1989.tb02274.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

polymerase chain reaction acute myelocytic leukemia acute lymphoblastic leukemia chronic myelocytic leukemia chronic lymphocytic leukemia myelodysplastic syndrome refractory anemia refractory anemia with excess of blasts refractory anemia with excess of blasts in transformation bone marrow transplantation nucleated cell count French‐American‐British

11 in total

1. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

Authors: R K Saiki; S Scharf; F Faloona; K B Mullis; G T Horn; H A Erlich; N Arnheim
Journal: Science Date: 1985-12-20 Impact factor: 47.728

Mutations of N-ras oncogene in myelodysplastic syndromes and leukemias detected by polymerase chain reaction.

1. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

2. Activation mechanism of the N-ras oncogene in human leukemias detected by synthetic oligonucleotide probes.

3. Isolation of genomic DNA.

4. Structure and activation of the human N-ras gene.

5. An activated rasN gene: detected in late but not early passage human PA1 teratocarcinoma cells.

6. Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia.

7. Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes.

8. RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation.

9. Mutation of Ki-ras and N-ras oncogenes in myelodysplastic syndromes.

10. A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome.

1. Point mutation in codon 61 of N-RAS genes in human myeloma cell lines.

2. Transforming genes and chromosome aberrations in therapy-related leukemia and myelodysplastic syndrome.

3. A simple method for detecting single base substitutions and its application to HLA-DPB1 typing.