Hideo Matsumoto1, Hisako Kubota2, Masaharu Higashida2, Eisaku Yoden3, Junichi Hiratsuka3, Ken Haruma4, Masafumi Nakamura2, Toshihiro Hirai2. 1. Department of Digestive Surgery, Kawasaki Medical School, Kurashiki City, Okayama, Japan h-matsu@med.kawasaki-m.ac.jp. 2. Department of Digestive Surgery, Kawasaki Medical School, Kurashiki City, Okayama, Japan. 3. Department of Radiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan. 4. Department of Gastroenterological Medicine, Kawasaki Medical School, Kurashiki City, Okayama, Japan.
Abstract
BACKGROUND: We tried a new regimen of docetaxel / TS-1 (tegafur-gimestat-otastat potassium) combined with radiation for squamous cell carcinoma of the esophagus in a phase II trial. PATIENTS AND METHODS: The patients, whose tumor invaded other organs without other organ metastasis, were given TS-1 (60 mg/m2/day) from days 1 to 14, and docetaxel (20-30 mg/m2) on days 1 and 8. They received radiation in 2.0 Gy from days 1 to 21. Patients were given a seven-day rest after the first course, and then were treated with the same regimen from days 28 to 49. RESULTS: Seventeen cases were enrolled in the study. The response rate was 76.4% (13/17). The overall 5-year survival rate was 29.6% (5/17) and median survival time was 15.2 months. Adverse events more than grade 3 occurred in 10 cases. CONCLUSION: This combination therapy may be one of the most effective treatments because of its lower rate of non-hematological adverse events and higher response rate. Three cases also underwent salvage surgery when the tumor recurred, and in one case, chemoradiation to a metastatic nodule on the thoracic wall was added. Copyright
BACKGROUND: We tried a new regimen of docetaxel / TS-1 (tegafur-gimestat-otastat potassium) combined with radiation for squamous cell carcinoma of the esophagus in a phase II trial. PATIENTS AND METHODS: The patients, whose tumor invaded other organs without other organ metastasis, were given TS-1 (60 mg/m2/day) from days 1 to 14, and docetaxel (20-30 mg/m2) on days 1 and 8. They received radiation in 2.0 Gy from days 1 to 21. Patients were given a seven-day rest after the first course, and then were treated with the same regimen from days 28 to 49. RESULTS: Seventeen cases were enrolled in the study. The response rate was 76.4% (13/17). The overall 5-year survival rate was 29.6% (5/17) and median survival time was 15.2 months. Adverse events more than grade 3 occurred in 10 cases. CONCLUSION: This combination therapy may be one of the most effective treatments because of its lower rate of non-hematological adverse events and higher response rate. Three cases also underwent salvage surgery when the tumor recurred, and in one case, chemoradiation to a metastatic nodule on the thoracic wall was added. Copyright