Dirk Rades1, Stefan Huttenlocher2, Steven E Schild3, Tobias Bartscht4. 1. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany Rades.Dirk@gmx.net. 2. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany. 3. Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A. 4. Department of Medical Oncology and Hematology, University of Lübeck, Lübeck, Germany.
Abstract
BACKGROUND/AIM: Pancreatic cancer is an extremely rare entity in patients with metastatic epidural spinal cord compression (MESCC). This study aimed to identify prognostic factors for functional outcome and survival following irradiation. PATIENTS AND METHODS: Ten variables were investigated in 15 patients: age, gender, performance score, time from diagnosis of pancreatic cancer to MESCC, number of involved vertebrae, ambulatory status, bone metastases, organ metastases, time developing motor deficits, and the radiation schedule (1×8 Gy vs. fractionated radiotherapy schedules). RESULTS: Better post-treatment motor function was significantly associated with absence of organ metastases (p=0.025). Better survival was also significantly associated with absence of organ metastases: 6-month survival rates were 100% and 9%, respectively (p=0.006). The radiation schedule had no significant impact on treatment outcomes. CONCLUSION: Patients with organ metastases have a very limited life expectancy and are good candidates for irradiation with 1×8 Gy instead of fractionated schedules. Copyright
BACKGROUND/AIM: Pancreatic cancer is an extremely rare entity in patients with metastatic epidural spinal cord compression (MESCC). This study aimed to identify prognostic factors for functional outcome and survival following irradiation. PATIENTS AND METHODS: Ten variables were investigated in 15 patients: age, gender, performance score, time from diagnosis of pancreatic cancer to MESCC, number of involved vertebrae, ambulatory status, bone metastases, organ metastases, time developing motor deficits, and the radiation schedule (1×8 Gy vs. fractionated radiotherapy schedules). RESULTS: Better post-treatment motor function was significantly associated with absence of organ metastases (p=0.025). Better survival was also significantly associated with absence of organ metastases: 6-month survival rates were 100% and 9%, respectively (p=0.006). The radiation schedule had no significant impact on treatment outcomes. CONCLUSION:Patients with organ metastases have a very limited life expectancy and are good candidates for irradiation with 1×8 Gy instead of fractionated schedules. Copyright
Authors: Luis Diaz-Aguilar; Usman Khan; Ronald Sahyouni; Nolan James Brown; Scott Olson; Joseph Anthony Osorio Journal: Surg Neurol Int Date: 2020-09-05
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