BACKGROUND: Angiogenic molecular markers such as vascular endothelial growth factor and tumor microvessel density reflect prognosis of human cancers. The present study clarified the usefulness of endothelial marker endoglin (CD 105) by assessing microvessel density in esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS: We immunohistochemically investigated CD105, CD31, and vascular endothelial growth factor-A VEGF-A expression in primary esophageal squamous cell carcinoma specimens from 142 patients. RESULTS: Microvessel density was 35.9±21.2 for CD105 and 46.3±25.4 for CD31. CD105 microvessel density was significantly associated with tumor length, tumor invasion depth, lymph node metastasis, stage, lymphatic invasion, venous invasion, and VEGF-A expression; its correlation with almost all clinicopathological parameters was stronger than CD31 microvessel density. And significantly better prognosis was achieved in patients with low, compared to high CD105, microvessel density. CONCLUSION: CD105 microvessel density reflected the degree of angiogenesis and prognosis in patients with esophageal squamous cell carcinoma. Copyright
BACKGROUND: Angiogenic molecular markers such as vascular endothelial growth factor and tumor microvessel density reflect prognosis of humancancers. The present study clarified the usefulness of endothelial marker endoglin (CD 105) by assessing microvessel density in esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS: We immunohistochemically investigated CD105, CD31, and vascular endothelial growth factor-AVEGF-A expression in primary esophageal squamous cell carcinoma specimens from 142 patients. RESULTS: Microvessel density was 35.9±21.2 for CD105 and 46.3±25.4 for CD31. CD105 microvessel density was significantly associated with tumor length, tumor invasion depth, lymph node metastasis, stage, lymphatic invasion, venous invasion, and VEGF-A expression; its correlation with almost all clinicopathological parameters was stronger than CD31 microvessel density. And significantly better prognosis was achieved in patients with low, compared to high CD105, microvessel density. CONCLUSION: CD105 microvessel density reflected the degree of angiogenesis and prognosis in patients with esophageal squamous cell carcinoma. Copyright
Authors: Vincent Q Sier; Joost R van der Vorst; Paul H A Quax; Margreet R de Vries; Elham Zonoobi; Alexander L Vahrmeijer; Ilona A Dekkers; Lioe-Fee de Geus-Oei; Anke M Smits; Weibo Cai; Cornelis F M Sier; Marie José T H Goumans; Lukas J A C Hawinkels Journal: Int J Mol Sci Date: 2021-04-30 Impact factor: 5.923
Authors: Claudia Ollauri-Ibáñez; Elena Núñez-Gómez; Cristina Egido-Turrión; Laura Silva-Sousa; Elena Díaz-Rodríguez; Alicia Rodríguez-Barbero; José M López-Novoa; Miguel Pericacho Journal: Angiogenesis Date: 2020-01-03 Impact factor: 9.596