Michael W Epperly1, Julie P Goff1, Darcy Franicola1, Hong Wang1, Peter Wipf2, Song Li3, Joel S Greenberger4. 1. Department of Radiation Oncology, UPCI Cancer Institute, Pittsburgh, PA, USA. 2. Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, U.S.A. Center for Chemical Methodologies & Library Development, University of Pittsburgh, Pittsburgh, PA, U.S.A. 3. Department of Pharmaceutical Science, University of Pittsburgh, Pittsburgh, PA, U.S.A. 4. Department of Radiation Oncology, UPCI Cancer Institute, Pittsburgh, PA, USA greenbergerjs@upmc.edu.
Abstract
BACKGROUND/AIM: To determine whether Gramicidin S (GS)-nitroxide, JP4-039, esophageal radiation protection protected lung tumors in a transgenic model, LoxP-Stoop-LoxP Kristen Rat Sarcoma Viral oncogene (LSL-K-RAS) mice were administered intra-tracheal- Carbapenem-resistant Enterobacteriaceae (CRE) recombinase, bilateral lung tumors were confirmed at 11 weeks, then thoracic irradiation was delivered. MATERIALS AND METHODS: Mice received single-fraction 15 Gy or 24 Gy to both lungs, in subgroups receiving intraesophageal administration 10 min before irradiation of JP4-039 (in F15 emulsion) tumor size reduction and survival were investigated. Mice were followed for survival, and reduction in tumor size. RESULTS: There was no evidence of tumor radioprotection in mice receiving JP4-039/F15. CONCLUSION: Intraesophageal radioprotective small-molecule antioxidant therapy protects normal tissue but not tumor tissue in mice with transgenic lung tumors.
BACKGROUND/AIM: To determine whether Gramicidin S (GS)-nitroxide, JP4-039, esophageal radiation protection protected lung tumors in a transgenic model, LoxP-Stoop-LoxP Kristen RatSarcoma Viral oncogene (LSL-K-RAS) mice were administered intra-tracheal- Carbapenem-resistant Enterobacteriaceae (CRE) recombinase, bilateral lung tumors were confirmed at 11 weeks, then thoracic irradiation was delivered. MATERIALS AND METHODS:Mice received single-fraction 15 Gy or 24 Gy to both lungs, in subgroups receiving intraesophageal administration 10 min before irradiation of JP4-039 (in F15 emulsion) tumor size reduction and survival were investigated. Mice were followed for survival, and reduction in tumor size. RESULTS: There was no evidence of tumor radioprotection in mice receiving JP4-039/F15. CONCLUSION: Intraesophageal radioprotective small-molecule antioxidant therapy protects normal tissue but not tumor tissue in mice with transgenic lung tumors.
Authors: Michael W Epperly; Peter Wipf; Renee Fisher; Darcy Franicola; Jan Beumer; Song Li; Rhonda M Brand; Louis D Falo; Geza Erdos; Joel S Greenberger Journal: In Vivo Date: 2018 Sep-Oct Impact factor: 2.155
Authors: Stephanie Thermozier; Wen Hou; Xichen Zhang; Donna Shields; Renee Fisher; Hulya Bayir; Valerian Kagan; Jian Yu; Bing Liu; Ivet Bahar; Michael W Epperly; Peter Wipf; Hong Wang; M Saiful Huq; Joel S Greenberger Journal: Radiat Res Date: 2020-03-05 Impact factor: 2.841
Authors: Michael W Epperly; Joshua R Sacher; Tanja Krainz; Xiaolin Zhang; Peter Wipf; Mary Liang; Renee Fisher; Song Li; Hong Wang; Joel S Greenberger Journal: In Vivo Date: 2017-01-02 Impact factor: 2.155
Authors: John Willis; Michael W Epperly; Renee Fisher; Xichen Zhang; Donna Shields; Wen Hou; Hong Wang; Song Li; Peter Wipf; Kalindi Parmar; Eva Guinan; Justin Steinman; Joel S Greenberger Journal: Radiat Res Date: 2018-03-27 Impact factor: 2.841
Authors: Susan Christner; Jianxia Guo; Robert A Parise; Melanie Ringeval; Adam T Hoye; Peter Wipf; Michael W Epperly; Joel S Greenberger; Jan H Beumer; Julie L Eiseman Journal: J Pharm Biomed Anal Date: 2017-12-12 Impact factor: 3.935
Authors: Thomas J Quinn; Xuanfeng Ding; Xiaoqiang Li; George D Wilson; Katie Buelow; Aranee Sivananthan; Stephanie Thermozier; Andrew Henderson; Michael W Epperly; Darcy Franicola; Peter Wipf; Joel S Greenberger; Craig W Stevens; Peyman Kabolizadeh Journal: In Vivo Date: 2019 Nov-Dec Impact factor: 2.155