| Literature DB >> 24982181 |
Jingwen Wu1, Jianqiang Bao2, Minkyung Kim3, Shuiqiao Yuan2, Chong Tang2, Huili Zheng2, Grant S Mastick3, Chen Xu4, Wei Yan5.
Abstract
Ablation of a single miRNA gene rarely leads to a discernable developmental phenotype in mice, in some cases because of compensatory effects by other functionally related miRNAs. Here, we report that simultaneous inactivation of two functionally related miRNA clusters (miR-34b/c and miR-449) encoding five miRNAs (miR-34b, miR-34c, miR-449a, miR-449b, and miR-449c) led to sexually dimorphic, partial perinatal lethality, growth retardation, and infertility. These developmental defects correlated with the dysregulation of ∼ 240 target genes, which are mainly involved in three major cellular functions, including cell-fate control, brain development and microtubule dynamics. Our data demonstrate an essential role of a miRNA family in brain development, motile ciliogenesis, and spermatogenesis.Entities:
Keywords: airway obstruction; egg transport; forebrain; oviduct
Mesh：
Substances：
Year: 2014 PMID： 24982181 PMCID： PMC4104921 DOI： 10.1073/pnas.1407777111
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205