Literature DB >> 24981634

Kif7 keeps cilia tips in shape.

Lotte B Pedersen1, Anna Akhmanova2.   

Abstract

The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. Kif7 is now found to inhibit microtubule growth to restrict and coordinate the length of axonemal microtubules at the ciliary tip. Such Kif7-mediated organization of the ciliary tip compartment regulates Gli activity and is proposed to be required for correct Hedgehog signalling.

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Year:  2014        PMID： 24981634     DOI： 10.1038/ncb2997

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  17 in total

1.  IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.

Authors:  Brian T Keady; Rajeev Samtani; Kimimasa Tobita; Maiko Tsuchya; Jovenal T San Agustin; John A Follit; Julie A Jonassen; Ramiah Subramanian; Cecilia W Lo; Gregory J Pazour
Journal:  Dev Cell       Date:  2012-05-15       Impact factor: 12.270

2.  CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.

Authors:  Babet van der Vaart; Wilhelmina E van Riel; Harinath Doodhi; Josta T Kevenaar; Eugene A Katrukha; Laura Gumy; Benjamin P Bouchet; Ilya Grigoriev; Samantha A Spangler; Ka Lou Yu; Phebe S Wulf; Jingchao Wu; Gideon Lansbergen; Eljo Y van Battum; R Jeroen Pasterkamp; Yuko Mimori-Kiyosue; Jeroen Demmers; Natacha Olieric; Ivan V Maly; Casper C Hoogenraad; Anna Akhmanova
Journal:  Dev Cell       Date:  2013-10-10       Impact factor: 12.270

3.  KIF19A is a microtubule-depolymerizing kinesin for ciliary length control.

Authors:  Shinsuke Niwa; Kazuo Nakajima; Harukata Miki; Yusuke Minato; Doudou Wang; Nobutaka Hirokawa
Journal:  Dev Cell       Date:  2012-11-15       Impact factor: 12.270

4.  The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

Authors:  Setsu Endoh-Yamagami; Marie Evangelista; Deanna Wilson; Xiaohui Wen; Jan-Willem Theunissen; Khanhky Phamluong; Matti Davis; Suzie J Scales; Mark J Solloway; Frederic J de Sauvage; Andrew S Peterson
Journal:  Curr Biol       Date:  2009-07-09       Impact factor: 10.834

5.  The Microtubule plus end-tracking protein EB1 is localized to the flagellar tip and basal bodies in Chlamydomonas reinhardtii.

Authors:  Lotte B Pedersen; Stefan Geimer; Roger D Sloboda; Joel L Rosenbaum
Journal:  Curr Biol       Date:  2003-11-11       Impact factor: 10.834

6.  The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.

Authors:  Helen Oi-Lam Cheung; Xiaoyun Zhang; Ana Ribeiro; Rong Mo; Shigeru Makino; Vijitha Puviindran; Kelvin K L Law; James Briscoe; Chi-Chung Hui
Journal:  Sci Signal       Date:  2009-06-23       Impact factor: 8.192

7.  Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.

Authors:  Christopher W Wilson; Catherine T Nguyen; Miao-Hsueh Chen; Jehn-Hsiahn Yang; Rhodora Gacayan; Jie Huang; Jau-Nian Chen; Pao-Tien Chuang
Journal:  Nature       Date:  2009-03-22       Impact factor: 49.962

8.  Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo.

Authors:  Ashish Kumar Maurya; Jin Ben; Zhonghua Zhao; Raymond Teck Ho Lee; Weixin Niah; Ashley Shu Mei Ng; Audrey Iyu; Weimiao Yu; Stone Elworthy; Fredericus J M van Eeden; Philip William Ingham
Journal:  PLoS Genet       Date:  2013-12-05       Impact factor: 5.917

9.  The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.

Authors:  Mu He; Radhika Subramanian; Fiona Bangs; Tatiana Omelchenko; Karel F Liem; Tarun M Kapoor; Kathryn V Anderson
Journal:  Nat Cell Biol       Date:  2014-06-22       Impact factor: 28.824

10.  EB1 recognizes the nucleotide state of tubulin in the microtubule lattice.

Authors:  Marija Zanic; Jeffrey H Stear; Anthony A Hyman; Jonathon Howard
Journal:  PLoS One       Date:  2009-10-23       Impact factor: 3.240
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  8 in total

1.  Arl3 and RP2 regulate the trafficking of ciliary tip kinesins.

Authors:  Nele Schwarz; Amelia Lane; Katarina Jovanovic; David A Parfitt; Monica Aguila; Clare L Thompson; Lyndon da Cruz; Peter J Coffey; J Paul Chapple; Alison J Hardcastle; Michael E Cheetham
Journal:  Hum Mol Genet       Date:  2017-07-01       Impact factor: 6.150

Review 2.  Cilia Distal Domain: Diversity in Evolutionarily Conserved Structures.

Authors:  Helena Soares; Bruno Carmona; Sofia Nolasco; Luís Viseu Melo; João Gonçalves
Journal:  Cells       Date:  2019-02-14       Impact factor: 6.600

Review 3.  Co-occurrence of mutations in KIF7 and KIAA0556 in Joubert syndrome with ocular coloboma, pituitary malformation and growth hormone deficiency: a case report and literature review.

Authors:  Marcello Niceta; Maria Lisa Dentici; Andrea Ciolfi; Romana Marini; Sabina Barresi; Francesca Romana Lepri; Antonio Novelli; Enrico Bertini; Marco Cappa; Maria Cristina Digilio; Bruno Dallapiccola; Marco Tartaglia
Journal:  BMC Pediatr       Date:  2020-03-12       Impact factor: 2.125

4.  Balancing the length of the distal tip by septins is key for stability and signalling function of primary cilia.

Authors:  Taishi Kanamaru; Annett Neuner; Bahtiyar Kurtulmus; Gislene Pereira
Journal:  EMBO J       Date:  2021-11-22       Impact factor: 11.598

Review 5.  Control of Hedgehog Signalling by the Cilia-Regulated Proteasome.

Authors:  Christoph Gerhardt; Antonia Wiegering; Tristan Leu; Ulrich Rüther
Journal:  J Dev Biol       Date:  2016-09-03

Review 6.  Signaling through the Primary Cilium.

Authors:  Gabrielle Wheway; Liliya Nazlamova; John T Hancock
Journal:  Front Cell Dev Biol       Date:  2018-02-08

Review 7.  The Role of Hedgehog Signalling in the Formation of the Ventricular Septum.

Authors:  Antonia Wiegering; Ulrich Rüther; Christoph Gerhardt
Journal:  J Dev Biol       Date:  2017-12-12

Review 8.  GLI3: a mediator of genetic diseases, development and cancer.

Authors:  Stephan J Matissek; Sherine F Elsawa
Journal:  Cell Commun Signal       Date:  2020-04-03       Impact factor: 7.525
  8 in total

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