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Literature DB >> 24981626

Physiology-based pharmacokinetic modeling: ready to be used.

Abstract

Physiology-based pharmacokinetic (PBPK) modeling is well recognized as a technology for mechanistically simulating and predicting the fate of substances in a mammalian body. Today, the demand for this methodology is higher than ever. The pharma industry and regulatory agencies are looking for new methods, which help to speed up and increase the efficiency of the development process for new drugs. Implementing PBPK modeling in the drug research and development workflow contributes significantly to reach this goal.:

Entities: Species

Year: 2004 PMID： 24981626 DOI： 10.1016/j.ddtec.2004.09.006

Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749

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Cited

11 in total

1. BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems.

Authors: John F Graf; Bernhard J Scholz; Maria I Zavodszky
Journal: J Pharmacokinet Pharmacodyn Date: 2011-12-10 Impact factor: 2.745

2. Advances in Nuclear Magnetic Resonance for Drug Discovery.

Authors: Robert Powers
Journal: Expert Opin Drug Discov Date: 2009-10-01 Impact factor: 6.098

3. Whole-body physiology-based pharmacokinetics of caspofungin for general patients, intensive care unit patients and hepatic insufficiency patients.

Authors: Qian-Ting Yang; Ya-Jing Zhai; Lu Chen; Tao Zhang; Yan Yan; Ti Meng; Lei-Chao Liu; Li-Mei Chen; Xue Wang; Ya-Lin Dong
Journal: Acta Pharmacol Sin Date: 2018-05-31 Impact factor: 6.150

4. Physiology-based pharmacokinetics of caspofungin for adults and paediatrics.

Authors: Felix Stader; Gudrun Wuerthwein; Andreas H Groll; Joerg-Janne Vehreschild; Oliver A Cornely; Georg Hempel
Journal: Pharm Res Date: 2014-12-19 Impact factor: 4.200

Review 5. Physiologically-based PK/PD modelling of therapeutic macromolecules.

Authors: Peter Thygesen; Panos Macheras; Achiel Van Peer
Journal: Pharm Res Date: 2009-10-22 Impact factor: 4.200

6. Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations.

Authors: Markus Krauss; Kai Tappe; Andreas Schuppert; Lars Kuepfer; Linus Goerlitz
Journal: PLoS One Date: 2015-10-02 Impact factor: 3.240

Physiology-based pharmacokinetic modeling: ready to be used.

1. BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems.

2. Advances in Nuclear Magnetic Resonance for Drug Discovery.

3. Whole-body physiology-based pharmacokinetics of caspofungin for general patients, intensive care unit patients and hepatic insufficiency patients.

4. Physiology-based pharmacokinetics of caspofungin for adults and paediatrics.

Review 5. Physiologically-based PK/PD modelling of therapeutic macromolecules.

6. Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations.

7. Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification.

8. A comprehensive framework for physiologically based pharmacokinetic modelling in Matlab^®.

9. Insights from pharmacokinetic models of host-microbiome drug metabolism.

10. Integrating cellular metabolism into a multiscale whole-body model.