Literature DB >> 24981501

The synthesis of well-defined heparin and heparan sulfate fragments.

Jeroen D C Codée1, Herman S Overkleeft1, Gijsbert A van der Marel1, Constant A A van Boeckel2.   

Abstract

Heparin and heparan sulfate are key players in a plethora of physiological processes. Organic synthesis is the method of choice for the production of these oligosaccharides and their derivatives and analogues. The highly complex structure of these polysaccharides presents a formidable synthetic challenge and the incorporation of the full array of variations in oligosaccharides of significant length is a daunting task. This review records the development of strategies to access these exciting biomolecules.:
© 2004 Elsevier Ltd . All rights reserved.

Entities:  

Year:  2004        PMID： 24981501     DOI： 10.1016/j.ddtec.2004.11.017

Source DB:  PubMed          Journal:  Drug Discov Today Technol        ISSN： 1740-6749


  9 in total

1.  Obstacles and solutions for chemical synthesis of syndecan-3 (53-62) glycopeptides with two heparan sulfate chains.

Authors:  Weizhun Yang; Keisuke Yoshida; Bo Yang; Xuefei Huang
Journal:  Carbohydr Res       Date:  2016-10-20       Impact factor: 2.104

Review 2.  Chemoenzymatic synthesis of the next generation of ultralow MW heparin therapeutics.

Authors:  Sayaka Masuko; Robert J Linhardt
Journal:  Future Med Chem       Date:  2012-03       Impact factor: 3.808

3.  Homoserine as an Aspartic Acid Precursor for Synthesis of Proteoglycan Glycopeptide Containing Aspartic Acid and a Sulfated Glycan Chain.

Authors:  Weizhun Yang; Sherif Ramadan; Bo Yang; Keisuke Yoshida; Xuefei Huang
Journal:  J Org Chem       Date:  2016-11-10       Impact factor: 4.354

4.  Automated Solid Phase Assisted Synthesis of a Heparan Sulfate Disaccharide Library.

Authors:  Sherif Ramadan; Guowei Su; Kedar Baryal; Linda C Hsieh-Wilson; Jian Liu; Xuefei Huang
Journal:  Org Chem Front       Date:  2022-04-19       Impact factor: 5.456

5.  Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies.

Authors:  Sailaja Arungundram; Kanar Al-Mafraji; Jinkeng Asong; Franklin E Leach; I Jonathan Amster; Andre Venot; Jeremy E Turnbull; Geert-Jan Boons
Journal:  J Am Chem Soc       Date:  2009-12-02       Impact factor: 15.419

6.  Chemical synthesis of a heparan sulfate glycopeptide: syndecan-1.

Authors:  Bo Yang; Keisuke Yoshida; Zhaojun Yin; Hang Dai; Herbert Kavunja; Mohammad H El-Dakdouki; Suttipun Sungsuwan; Steven B Dulaney; Xuefei Huang
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-07       Impact factor: 15.336

Review 7.  Strategies in synthesis of heparin/heparan sulfate oligosaccharides: 2000-present.

Authors:  Steven B Dulaney; Xuefei Huang
Journal:  Adv Carbohydr Chem Biochem       Date:  2012       Impact factor: 12.200

8.  Fluorous-assisted chemoenzymatic synthesis of heparan sulfate oligosaccharides.

Authors:  Chao Cai; Demetria M Dickinson; Lingyun Li; Sayaka Masuko; Matt Suflita; Victor Schultz; Shawn D Nelson; Ujjwal Bhaskar; Jian Liu; Robert J Linhardt
Journal:  Org Lett       Date:  2014-04-04       Impact factor: 6.005

9.  Divergent Synthesis of Heparan Sulfate Oligosaccharides.

Authors:  Steven B Dulaney; Yongmei Xu; Peng Wang; Gopinath Tiruchinapally; Zhen Wang; Jolian Kathawa; Mohammad H El-Dakdouki; Bo Yang; Jian Liu; Xuefei Huang
Journal:  J Org Chem       Date:  2015-12-04       Impact factor: 4.354
  9 in total

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