| Literature DB >> 24981494 |
Abstract
In vitro combinatorial chemistry represents a variety of technologies where the selection and synthesis of novel molecules is performed in one integrated process. In its application towards drug discovery, the biological target is used to select and/or to amplify compounds out of a large pool of potential combinatorial compound library members. Recent examples provide a first proof-of-concept that dynamic combinatorial libraries or 'click chemistry' are able to discover highly potent and selective small molecule inhibitors of target enzymes.:Year: 2004 PMID： 24981494 DOI： 10.1016/j.ddtec.2004.11.019
Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749