Literature DB >> 24981262

Fishing for targets: novel approaches using small molecule baits.

Katrin Szardenings1, Bei Li2, Lifu Ma2, Min Wu2.   

Abstract

New technologies for target identification have emerged in the past few years. Driven by the development of novel proteomic tools and advances in analytical techniques, three new approaches have been successfully applied to drug discovery efforts by determining targets and off-targets. Recent progress in labeling live cells with activity-based probes will further aide a deeper understanding of the interaction of small molecules with a complex biological system on a molecular level.:
© 2004 Elsevier Ltd . All rights reserved.

Year:  2004        PMID: 24981262     DOI: 10.1016/j.ddtec.2004.08.009

Source DB:  PubMed          Journal:  Drug Discov Today Technol        ISSN: 1740-6749


  7 in total

1.  A universal method for fishing target proteins from mixtures of biomolecules using isothermal titration calorimetry.

Authors:  Xingding Zhou; Qingxiang Sun; R Manjunatha Kini; J Sivaraman
Journal:  Protein Sci       Date:  2008-07-11       Impact factor: 6.725

2.  Application of isothermal titration calorimetry and column chromatography for identification of biomolecular targets.

Authors:  Xingding Zhou; R Manjunatha Kini; J Sivaraman
Journal:  Nat Protoc       Date:  2011-01-20       Impact factor: 13.491

Review 3.  Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays.

Authors:  Marcela Cristina de Moraes; Carmen Lucia Cardoso; Cláudia Seidl; Ruin Moaddel; Quezia Bezerra Cass
Journal:  Curr Pharm Des       Date:  2016       Impact factor: 3.116

4.  Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data.

Authors:  Alexander Mitsos; Ioannis N Melas; Paraskeuas Siminelakis; Aikaterini D Chairakaki; Julio Saez-Rodriguez; Leonidas G Alexopoulos
Journal:  PLoS Comput Biol       Date:  2009-12-04       Impact factor: 4.475

5.  A "clickable" MTX reagent as a practical tool for profiling small-molecule-intracellular target interactions via MASPIT.

Authors:  Martijn D P Risseeuw; Dries J H De Clercq; Sam Lievens; Ulrik Hillaert; Davy Sinnaeve; Freya Van den Broeck; José C Martins; Jan Tavernier; Serge Van Calenbergh
Journal:  ChemMedChem       Date:  2013-01-22       Impact factor: 3.466

6.  Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.

Authors:  Grace Mugumbate; Vitor Mendes; Michal Blaszczyk; Mohamad Sabbah; George Papadatos; Joel Lelievre; Lluis Ballell; David Barros; Chris Abell; Tom L Blundell; John P Overington
Journal:  Front Pharmacol       Date:  2017-09-26       Impact factor: 5.810

7.  An isothermal shift assay for proteome scale drug-target identification.

Authors:  Kerri A Ball; Kristofor J Webb; Stephen J Coleman; Kira A Cozzolino; Jeremy Jacobsen; Kevin R Jones; Michael H B Stowell; William M Old
Journal:  Commun Biol       Date:  2020-02-14
  7 in total

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