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Literature DB >> 24981095

Drying methods for protein pharmaceuticals.

Morten Jonas Maltesen¹, Marco van de Weert².

Abstract

Removal of water is a common method to prolong the storage stability of protein formulations. Traditionally, freeze-drying has been the method of choice, but spray drying and supercritical drying have gained increased interest in the past decade. The proper choice of drying technology has a significant impact on the final pharmaceutical product and on the overall economy of the process.:

Entities: Chemical

Year: 2008 PMID： 24981095 DOI： 10.1016/j.ddtec.2008.11.001

Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749

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Cited

13 in total

1. Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy.

Authors: Morten Jonas Maltesen; Marco van de Weert; Holger Grohganz
Journal: AAPS PharmSciTech Date: 2012-05-15 Impact factor: 3.246

2. A Multiparticulate Delivery System for Potential Colonic Targeting Using Bovine Serum Albumin as a Model Protein : Theme: Formulation and Manufacturing of Solid Dosage Forms Guest Editors: Tony Zhou and Tonglei Li.

Authors: Bowen Jiang; Hua Yu; Yongrong Zhang; Hanping Feng; Stephen W Hoag
Journal: Pharm Res Date: 2017-08-14 Impact factor: 4.200

10. The identification of goat peroxiredoxin-5 and the evaluation and enhancement of its stability by nanoparticle formation.

Authors: Xiaozhou Feng; Juanjuan Liu; Shuai Fan; Fan Liu; Yadong Li; Yuanyuan Jin; Liping Bai; Zhaoyong Yang
Journal: Sci Rep Date: 2016-04-14 Impact factor: 4.379

Drying methods for protein pharmaceuticals.

1. Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy.

2. A Multiparticulate Delivery System for Potential Colonic Targeting Using Bovine Serum Albumin as a Model Protein : Theme: Formulation and Manufacturing of Solid Dosage Forms Guest Editors: Tony Zhou and Tonglei Li.

3. Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR.

4. Spray-Dried and Spray-Freeze-Dried Powder Formulations of an Anti-Interleukin-4Rα Antibody for Pulmonary Delivery.

5. Formulation of High-Performance Dry Powder Aerosols for Pulmonary Protein Delivery.

Review 6. Pharmaceutical protein solids: Drying technology, solid-state characterization and stability.

Review 7. Developments in the formulation and delivery of spray dried vaccines.

8. Modeling and optimization of radish root extract drying as peroxidase source using spouted bed dryer.

9. Evaluation of nano spray drying as a method for drying and formulation of therapeutic peptides and proteins.

10. The identification of goat peroxiredoxin-5 and the evaluation and enhancement of its stability by nanoparticle formation.