Literature DB >> 2498085

The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.

A M Nunez1, M Berry, J L Imler, P Chambon.   

Abstract

Expression of the pS2 gene which is transcriptionally controlled by oestrogens in the breast cancer cell line MCF-7 is oestrogen independent in stomach mucosa. We show here that the level of MCF-7 cell pS2 mRNA can also be increased by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). We further demonstrate, using transient transfection assays, that the -428 to -332 5' flanking sequence of the pS2 gene contains DNA enhancer elements responsive to oestrogens, TPA, EGF, the c-Ha-ras oncoprotein and the c-jun protein.

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Year:  1989        PMID： 2498085      PMCID： PMC400880          DOI： 10.1002/j.1460-2075.1989.tb03443.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  71 in total

Review 1.  Transforming growth factor alpha.

Authors:  R Derynck
Journal:  Cell       Date:  1988-08-26       Impact factor: 41.582

Review 2.  The molecular heterogeneity of protein kinase C and its implications for cellular regulation.

Authors:  Y Nishizuka
Journal:  Nature       Date:  1988-08-25       Impact factor: 49.962

3.  The 5' flanking region of the human pS2 gene mediates its transcriptional activation by estrogen in MCF-7 cells.

Authors:  M Roberts; J Wallace; J M Jeltsch; M Berry
Journal:  Biochem Biophys Res Commun       Date:  1988-02-29       Impact factor: 3.575

4.  The 'CC.Ar.GG' box. A protein-binding site common to transcription-regulatory regions of the cardiac actin, c-fos and interleukin-2 receptor genes.

Authors:  F Phan-Dinh-Tuy; D Tuil; F Schweighoffer; C Pinset; A Kahn; A Minty
Journal:  Eur J Biochem       Date:  1988-05-02

5.  Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor.

Authors:  C Nelson; V R Albert; H P Elsholtz; L I Lu; M G Rosenfeld
Journal:  Science       Date:  1988-03-18       Impact factor: 47.728

6.  v-jun is a transcriptional activator, but not in all cell-lines.

Authors:  J L Imler; E Ugarte; C Wasylyk; B Wasylyk
Journal:  Nucleic Acids Res       Date:  1988-04-11       Impact factor: 16.971

7.  Activation of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins.

Authors:  M E Martin; J Piette; M Yaniv; W J Tang; W R Folk
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

8.  Estrogens and growth factors induce the mRNA of the 52K-pro-cathepsin-D secreted by breast cancer cells.

Authors:  V Cavailles; P Augereau; M Garcia; H Rochefort
Journal:  Nucleic Acids Res       Date:  1988-03-25       Impact factor: 16.971

9.  Independent molecular pathways in initiation and loss of hormone responsiveness of breast carcinomas.

Authors:  S Sukumar; W P Carney; M Barbacid
Journal:  Science       Date:  1988-04-22       Impact factor: 47.728

10.  A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum.

Authors:  J L Imler; C Schatz; C Wasylyk; B Chatton; B Wasylyk
Journal:  Nature       Date:  1988-03-17       Impact factor: 49.962
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  58 in total

Review 1.  Peptide gene expression in gastrointestinal mucosal ulceration: ordered sequence or redundancy?

Authors:  W M Wong; R J Playford; N A Wright
Journal:  Gut       Date:  2000-02       Impact factor: 23.059

Review 2.  Intrinsic and Extrinsic Factors Governing the Transcriptional Regulation of ESR1.

Authors:  David K Lung; Rebecca M Reese; Elaine T Alarid
Journal:  Horm Cancer       Date:  2020-06-26       Impact factor: 3.869

3.  The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation.

Authors:  D Taupin; D C Wu; W K Jeon; K Devaney; T C Wang; D K Podolsky
Journal:  J Clin Invest       Date:  1999-05       Impact factor: 14.808

4.  High expression of the trefoil protein TFF1 in interval breast cancers.

Authors:  M Crosier; D Scott; R G Wilson; C D Griffiths; F E May; B R Westley
Journal:  Am J Pathol       Date:  2001-07       Impact factor: 4.307

5.  Functional interaction of hybrid response elements with wild-type and mutant steroid hormone receptors.

Authors:  M Truss; G Chalepakis; E P Slater; S Mader; M Beato
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

6.  Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16.

Authors:  C K Jiang; T Magnaldo; M Ohtsuki; I M Freedberg; F Bernerd; M Blumenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205

7.  Chromatin context dominates estrogen regulation of pS2 gene expression.

Authors:  Akua K Oduro; Michael K Fritsch; Fern E Murdoch
Journal:  Exp Cell Res       Date:  2008-07-15       Impact factor: 3.905

8.  RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas.

Authors:  A Thiagalingam; A De Bustros; M Borges; R Jasti; D Compton; L Diamond; M Mabry; D W Ball; S B Baylin; B D Nelkin
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

9.  Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts.

Authors:  R Klemenz; E Fröhli; A Aoyama; S Hoffmann; R J Simpson; R L Moritz; R Schäfer
Journal:  Mol Cell Biol       Date:  1991-02       Impact factor: 4.272

10.  Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors.

Authors:  A De; D G Brown; M A Gorman; M Carr; M R Sanderson; P S Freemont
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205
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