BACKGROUND: Urinary tract infections (UTIs) are widespread in renal transplant (RTx) recipients with asymptomatic bacteriuria (AB) as the predominant form. It is necessary to determine if AB is a risk factor for symptomatic UTIs. METHODS: We analyzed clinical data and urine cultures performed within the first 12 months after RTx in 209 consecutive patients undergoing RTx at Gdańsk Transplantation Center between January 2007 and December 2009. RESULTS: We observed 170 AB episodes in 83 patients. This accounted for 53% of all diagnosed UTIs in 111 patients, with more than half of AB episodes occurring during the first month post transplant. The most prevalent uropathogen was Enterococcus faecium (36.8%, n = 32) and, from the second month after RTx, Escherichia coli (54.2%, n = 45). Female gender, use of induction with anti-thymocyte globulin, comorbidity measured by Charlson Comorbidity Index, history of acute rejection, and cytomegalovirus infection were risk factors for developing AB, and no differences in risk factors were seen for developing a symptomatic UTI vs. an AB after RTx. All patients with AB received antibiotic therapy. AB was an independent risk factor for symptomatic UTIs, but only 21 of 152 episodes of symptomatic UTIs were preceded by AB with the same causative agent. CONCLUSIONS: AB is a common finding in the RTx population and AB episodes may be considered a risk factor for symptomatic infections. It remains to be determined if the treatment of AB in RTx patients is in fact helpful or harmful in preventing symptomatic infections.
BACKGROUND:Urinary tract infections (UTIs) are widespread in renal transplant (RTx) recipients with asymptomatic bacteriuria (AB) as the predominant form. It is necessary to determine if AB is a risk factor for symptomatic UTIs. METHODS: We analyzed clinical data and urine cultures performed within the first 12 months after RTx in 209 consecutive patients undergoing RTx at Gdańsk Transplantation Center between January 2007 and December 2009. RESULTS: We observed 170 AB episodes in 83 patients. This accounted for 53% of all diagnosed UTIs in 111 patients, with more than half of AB episodes occurring during the first month post transplant. The most prevalent uropathogen was Enterococcus faecium (36.8%, n = 32) and, from the second month after RTx, Escherichia coli (54.2%, n = 45). Female gender, use of induction with anti-thymocyte globulin, comorbidity measured by Charlson Comorbidity Index, history of acute rejection, and cytomegalovirus infection were risk factors for developing AB, and no differences in risk factors were seen for developing a symptomatic UTI vs. an AB after RTx. All patients with AB received antibiotic therapy. AB was an independent risk factor for symptomatic UTIs, but only 21 of 152 episodes of symptomatic UTIs were preceded by AB with the same causative agent. CONCLUSIONS: AB is a common finding in the RTx population and AB episodes may be considered a risk factor for symptomatic infections. It remains to be determined if the treatment of AB in RTx patients is in fact helpful or harmful in preventing symptomatic infections.
Authors: Johannes Korth; Julia Kukalla; Peter-Michael Rath; Sebastian Dolff; Marco Krull; Hana Guberina; Anja Bienholz; Benjamin Wilde; Stefan Becker; Birgit Ross; Olympia Evdoxia Anastasiou; Andreas Kribben; Oliver Witzke Journal: BMC Nephrol Date: 2017-05-19 Impact factor: 2.388
Authors: Sadiq Abu; Stephen O Asaolu; Martin C Igbokwe; Olalekan O Olatise; Kenenna Obiatuegwu; Uzodimma E Onwuasoanya; Adefola R Adetunbi Journal: Cureus Date: 2022-07-31
Authors: Rodrigo Rosado-Canto; Idalia Parra-Avila; Javier Tejeda-Maldonado; Cristopher Kauffman-Ortega; Francisco T Rodriguez-Covarrubias; Mariedel Trujeque-Matos; Rodrigo Cruz-Martínez; Ernesto Maravilla-Franco; Elia Criollo-Mora; José M Arreola-Guerra; Luis E Morales-Buenrostro; José Sifuentes-Osornio Journal: Nephrol Dial Transplant Date: 2020-11-01 Impact factor: 5.992