Literature DB >> 24980527

Targeting transcription factors in cancer: Challenges and evolving strategies.

Michele S Redell1, David J Tweardy2.   

Abstract

As investigators uncover the molecular pathways leading to cancer, an abundance of potential molecular targets is accumulating. Among these targets, transcription factors are especially promising. This review discusses the reasons for focusing targeting efforts on transcription factors and highlights some salient examples. The advantages and problems with current methods for targeting are summarized. Finally, we discuss the drug delivery technologies in development that may one day make transcription factor targeting a therapeutic reality.:
© 2006 Elsevier Ltd . All rights reserved.

Entities:  

Year:  2006        PMID： 24980527     DOI： 10.1016/j.ddtec.2006.09.010

Source DB:  PubMed          Journal:  Drug Discov Today Technol        ISSN： 1740-6749


  10 in total

1.  More Related Gene Pathways to Vincristine-Induced Death Events in a Human T-Acute Lymphoblastic Leukemia Cell Line.

Authors:  Azam Rashidbaghan; Ali Mostafaie; Yaghoub Yazdani; Kamran Mansouri
Journal:  Rep Biochem Mol Biol       Date:  2022-01

2.  Construction of a transcription factor-miRNA-mRNA interactive network elucidates underlying pathogenesis for osteosarcoma and validation by qRT-PCR.

Authors:  Fuxing Tang; Xiaohong Jiang; Shijie Liao; Yun Liu; Maolin He
Journal:  Medicine (Baltimore)       Date:  2022-10-14       Impact factor: 1.817

Review 3.  Clinical translation of genotyping and haplotyping data: implementation of in vivo pharmacology experience leading drug prescription to pharmacotyping.

Authors:  Ioannis S Vizirianakis
Journal:  Clin Pharmacokinet       Date:  2007       Impact factor: 6.447

4.  Principled multi-omic analysis reveals gene regulatory mechanisms of phenotype variation.

Authors:  Casey Hanson; Junmei Cairns; Liewei Wang; Saurabh Sinha
Journal:  Genome Res       Date:  2018-06-13       Impact factor: 9.043

5.  Chimeric NANOG repressors inhibit glioblastoma growth in vivo in a context-dependent manner.

Authors:  Monika Kuciak; Christophe Mas; Isabel Borges; Pilar Sánchez-Gómez; Ariel Ruiz I Altaba
Journal:  Sci Rep       Date:  2019-03-07       Impact factor: 4.379

Review 6.  Current Approaches for Personalized Therapy of Soft Tissue Sarcomas.

Authors:  Kirill I Kirsanov; Ekaterina A Lesovaya; Timur I Fetisov; Beniamin Yu Bokhyan; Gennady A Belitsky; Marianna G Yakubovskaya
Journal:  Sarcoma       Date:  2020-03-31

7.  Identification of novel transcription factor-microRNA-mRNA co-regulatory networks in pulmonary large-cell neuroendocrine carcinoma.

Authors:  Cunliang Cai; Qianli Zeng; Guiliang Zhou; Xiangdong Mu
Journal:  Ann Transl Med       Date:  2021-01

8.  Identifying lncRNA- and Transcription Factor-Associated Regulatory Networks in the Cortex of Rats With Deep Hypothermic Circulatory Arrest.

Authors:  Mengya Liang; Yi Zhang; Shuangjiao Gan; Yunqi Liu; Huayang Li; Quan Liu; Haoliang Liu; Zhuoming Zhou; Huawei Wu; Guangxian Chen; Zhongkai Wu
Journal:  Front Genet       Date:  2021-12-17       Impact factor: 4.599

9.  Chemical probes that competitively and selectively inhibit Stat3 activation.

Authors:  Xuejun Xu; Moses M Kasembeli; Xueqing Jiang; Benjamin J Tweardy; David J Tweardy
Journal:  PLoS One       Date:  2009-03-10       Impact factor: 3.240

Review 10.  Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in Rhabdomyosarcoma.

Authors:  Thanh Hung Nguyen; Frederic G Barr
Journal:  Molecules       Date:  2018-10-28       Impact factor: 4.411
  10 in total

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