Prediction and classification of protein functions.

Data from large-scale genome projects, transcriptomics and proteomics experiments have provided scientists with a wealth of information establishing the basis for the investigation of cellular processes. To understand biological function beyond the single gene by the discovery and characterization of functional protein networks, bioinformatics analysis requires information about two additional attributes associated with the gene products: (i) high-level protein function prediction of experimentally uncharacterized proteins and (ii) systematic classification of protein function. This article describes the basic properties of protein classification systems and discusses examples of their implementation.: � 2006 Elsevier Ltd . All rights reserved.