Michael J Sanfelippo1, Jessica M Engel, Adedayo A Onitilo. 1. From the Department of Hematology/Coagulation Services, Marshfield Labs, Marshfield (Mr Sanfelippo), the Marshfield Clinic Cancer Care at St Michaels, Stevens Point (Ms Engel), and the Department of Hematology/Oncology, Marshfield Clinic Weston Center, Weston (Dr Onitilo), Wisconsin.
Abstract
CONTEXT: The results of studies among patients with antithrombin deficiency have suggested that the use of warfarin will increase the level of antithrombin. OBJECTIVE: To reevaluate the effect of warfarin on antithrombin levels using an automated amidolytic method in current use. DESIGN: Antithrombin levels were measured in patients who were receiving warfarin for atrial fibrillation and were compared with antithrombin levels in preoperative patients who had not received warfarin. RESULTS: Patients receiving warfarin had a mean antithrombin level of 100.40% (range, 81%-153%). Patients not receiving warfarin had a mean antithrombin level of 99.97% (range, 79%-120%). The Student t test was not significant for a difference between the mean antithrombin levels of the 2 populations. CONCLUSIONS: The use of warfarin does not increase the level of antithrombin in patients receiving the drug.
CONTEXT: The results of studies among patients with antithrombin deficiency have suggested that the use of warfarin will increase the level of antithrombin. OBJECTIVE: To reevaluate the effect of warfarin on antithrombin levels using an automated amidolytic method in current use. DESIGN:Antithrombin levels were measured in patients who were receiving warfarin for atrial fibrillation and were compared with antithrombin levels in preoperative patients who had not received warfarin. RESULTS:Patients receiving warfarin had a mean antithrombin level of 100.40% (range, 81%-153%). Patients not receiving warfarin had a mean antithrombin level of 99.97% (range, 79%-120%). The Student t test was not significant for a difference between the mean antithrombin levels of the 2 populations. CONCLUSIONS: The use of warfarin does not increase the level of antithrombin in patients receiving the drug.
Authors: Herbert Schöchl; Oliver Grottke; Ken Sutor; Kieron Dony; Martin Schreiber; Marco Ranucci; Peter W Collins Journal: Anesth Analg Date: 2017-11 Impact factor: 5.108