Jong Gyun Ahn1, Seong Yeol Choi2, Dong Soo Kim3, Ki Hwan Kim4. 1. Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Republic of Korea; Department of Medicine, The Graduate School of Yonsei University, Seoul, Republic of Korea. 2. Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. 3. Department of Medicine, The Graduate School of Yonsei University, Seoul, Republic of Korea; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. 4. Department of Medicine, The Graduate School of Yonsei University, Seoul, Republic of Korea; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: khkim99@yuhs.ac.
Abstract
BACKGROUND: Delta neutrophil index (DNI) has been reported to be useful in assessing the prognosis of suspected bacteraemia in adults. However, data in children are limited. The purpose of this study was to investigate the correlation between the DNI and bacteraemia in children and to compare DNI values between immunocompetent and immunocompromised hosts. METHODS: We retrospectively collected data on 8593 children who underwent simultaneous blood culture and DNI testing. DNI was determined with a blood cell analyser (ADVIA 120, Siemens, Inc.). The children were divided into immunocompromised (n=664) and immunocompetent groups (n=7929). RESULTS: DNI was higher in the bacteraemia group than in the non-bacteraemia group (P<0.001). According to the group, DNI was higher in immunocompromised than immunocompetent patients (P<0.001). Within the immunocompromised group, there was no significant difference between the bacteraemia and non-bacteraemia subgroups due to a higher DNI as compared to the immunocompetent group. CONCLUSIONS: DNI could be an additional method for the early diagnosis of bacteraemia in children. However, the use of DNI for the prediction of bacteraemia in immunocompromised cases has limitations. Further studies on the usefulness of DNI according to specific diseases are needed.
BACKGROUND: Delta neutrophil index (DNI) has been reported to be useful in assessing the prognosis of suspected bacteraemia in adults. However, data in children are limited. The purpose of this study was to investigate the correlation between the DNI and bacteraemia in children and to compare DNI values between immunocompetent and immunocompromised hosts. METHODS: We retrospectively collected data on 8593 children who underwent simultaneous blood culture and DNI testing. DNI was determined with a blood cell analyser (ADVIA 120, Siemens, Inc.). The children were divided into immunocompromised (n=664) and immunocompetent groups (n=7929). RESULTS: DNI was higher in the bacteraemia group than in the non-bacteraemia group (P<0.001). According to the group, DNI was higher in immunocompromised than immunocompetent patients (P<0.001). Within the immunocompromised group, there was no significant difference between the bacteraemia and non-bacteraemia subgroups due to a higher DNI as compared to the immunocompetent group. CONCLUSIONS: DNI could be an additional method for the early diagnosis of bacteraemia in children. However, the use of DNI for the prediction of bacteraemia in immunocompromised cases has limitations. Further studies on the usefulness of DNI according to specific diseases are needed.
Authors: Jae Hyon Park; Hyeong Ju Byeon; Keum Hwa Lee; Jong Wook Lee; Andreas Kronbichler; Michael Eisenhut; Jae Il Shin Journal: Inflamm Res Date: 2017-06-23 Impact factor: 4.575
Authors: Jung Won Lee; Seong Heon Kim; Se Jin Park; Keum Hwa Lee; Jae Hyon Park; Andreas Kronbichler; Michael Eisenhut; Ji Hong Kim; Jong Wook Lee; Jae Il Shin Journal: Sci Rep Date: 2017-02-07 Impact factor: 4.379