Literature DB >> 24977325

CD24 regulates stemness and the epithelial to mesenchymal transition through modulation of Notch1 mRNA stability by p38MAPK.

Juyeon Lim1, Kyung-min Lee1, Jaekyung Shim2, Incheol Shin3.   

Abstract

We report here that CD24 knockdown resulted in decreased expression of Notch1 in MCF-7 cells. CD24-downstream p38MAPK was shown to regulate Notch1 at the level of mRNA stability. We also found that CD24-mediated cell migration, invasion, mammosphere formation, and drug resistance was regulated by its downstream target Notch1. Together, our results indicate that CD24 may regulate the epithelial to mesenchymal transition and stemness through Notch1 signaling in breast cancer cells.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Breast cancer; CD24; CSC; EMT; Notch1

Mesh：

Substances：

Year:  2014        PMID： 24977325     DOI： 10.1016/j.abb.2014.06.022

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  9 in total

1.  Resveratrol Analog 4-Bromo-Resveratrol Inhibits Gastric Cancer Stemness through the SIRT3-c-Jun N-Terminal Kinase Signaling Pathway.

Authors:  Yun-Shen Tai; Yi-Shih Ma; Chun-Lin Chen; Hsin-Yi Tsai; Chin-Chuan Tsai; Meng-Chieh Wu; Chih-Yi Chen; Ming-Wei Lin
Journal:  Curr Issues Mol Biol       Date:  2021-12-22       Impact factor: 2.976

2.  CD24 promotes HCC progression via triggering Notch-related EMT and modulation of tumor microenvironment.

Authors:  Xin Wan; Ci Cheng; Qing Shao; Zhe Lin; Shuai Lu; Yun Chen
Journal:  Tumour Biol       Date:  2015-11-25

3.  CD24 expression as a marker for predicting clinical outcome and invasive activity in uterine cervical cancer.

Authors:  Tomohito Tanaka; Yoshito Terai; Yuhei Kogata; Keisuke Ashihara; Kazuya Maeda; Satoe Fujiwara; Saha Yoo; Yoshimichi Tanaka; Satoshi Tsunetoh; Hiroshi Sasaki; Masanori Kanemura; Akiko Tanabe; Masahide Ohmichi
Journal:  Oncol Rep       Date:  2015-09-08       Impact factor: 3.906

4.  CD24 expression and stem-associated features define tumor cell heterogeneity and tumorigenic capacities in a model of carcinogenesis.

Authors:  Paola Ortiz-Montero; Win-Yan Liu-Bordes; Arturo Londoño-Vallejo; Jean-Paul Vernot
Journal:  Cancer Manag Res       Date:  2018-11-16       Impact factor: 3.989

5.  Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization.

Authors:  Chetan P Hans; Neekun Sharma; Sidharth Sen; Shuai Zeng; Rishabh Dev; Yuexu Jiang; Advitiya Mahajan; Trupti Joshi
Journal:  Sci Rep       Date:  2019-05-29       Impact factor: 4.379

6.  CD24 Overexpression Is Associated with Poor Prognosis in Luminal A and Triple-Negative Breast Cancer.

Authors:  Mi Jeong Kwon; Jinil Han; Ji Hyun Seo; Kyoung Song; Hae Min Jeong; Jong-Sun Choi; Yu Jin Kim; Seon-Heui Lee; Yoon-La Choi; Young Kee Shin
Journal:  PLoS One       Date:  2015-10-07       Impact factor: 3.240

7.  Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma.

Authors:  Adrian Biddle; Luke Gammon; Xiao Liang; Daniela Elena Costea; Ian C Mackenzie
Journal:  EBioMedicine       Date:  2016-01-09       Impact factor: 8.143

Review 8.  Molecular Portrait of the Normal Human Breast Tissue and Its Influence on Breast Carcinogenesis.

Authors:  Madalin Marius Margan; Andreea Adriana Jitariu; Anca Maria Cimpean; Cristian Nica; Marius Raica
Journal:  J Breast Cancer       Date:  2016-06-24       Impact factor: 3.588

9.  Identification of grade and origin specific cell populations in serous epithelial ovarian cancer by single cell RNA-seq.

Authors:  Andrew J Shih; Andrew Menzin; Jill Whyte; John Lovecchio; Anthony Liew; Houman Khalili; Tawfiqul Bhuiya; Peter K Gregersen; Annette T Lee
Journal:  PLoS One       Date:  2018-11-01       Impact factor: 3.240
  9 in total

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