| Literature DB >> 24976526 |
Zejun Xu1, Kunru Guo, Jieshi Yu, Haili Sun, Jun Tang, Jie Shen, Klaus Müllen, Wantai Yang, Meizhen Yin.
Abstract
To date, perylene derivatives have not been explored as DNA intercalator to inhibit cancer cells by intercalating into the base pairs of DNA. Herein, a water-soluble perylene bisimide (PBDI) that efficiently intercalates into the base pairs of DNA is synthesized. Excitingly, PBDI is superior to the commercial DNA intercalator, amonafide, for specific nuclear accumulation and effective suppression of cancer cells and tumors.Entities:
Keywords: DNA intercalator; anticancer activity; nuclear accumulation; perylene bisimides; planar nanoscaffolds
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Year: 2014 PMID： 24976526 DOI： 10.1002/smll.201401262
Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281