Literature DB >> 24975719

NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels.

Serena Pillozzi1, Luca Gasparoli, Matteo Stefanini, Mirco Ristori, Massimo D'Amico, Enzo Alessio, Federica Scaletti, Andrea Becchetti, Annarosa Arcangeli, Luigi Messori.   

Abstract

We report here that the established anticancer ruthenium(iii) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic" antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these findings are discussed.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24975719     DOI： 10.1039/c4dt01356e

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  6 in total

1.  The antimetastatic drug NAMI-A potentiates the phenylephrine-induced contraction of aortic smooth muscle cells and induces a transient increase in systolic blood pressure.

Authors:  M Vadori; C Florio; B Groppo; M Cocchietto; S Pacor; S Zorzet; L Candussio; G Sava
Journal:  J Biol Inorg Chem       Date:  2015-05-16       Impact factor: 3.358

Review 2.  Bioactivity and Development of Small Non-Platinum Metal-Based Chemotherapeutics.

Authors:  Maria Grazia Ferraro; Marialuisa Piccolo; Gabriella Misso; Rita Santamaria; Carlo Irace
Journal:  Pharmaceutics       Date:  2022-04-28       Impact factor: 6.525

3.  Impact of low- and high-molecular-mass components of human serum on NAMI-A binding to transferrin.

Authors:  K Śpiewak; M Brindell
Journal:  J Biol Inorg Chem       Date:  2015-03-20       Impact factor: 3.358

4.  Antagonizing STAT5B dimerization with an osmium complex.

Authors:  Li-Juan Liu; Wanhe Wang; Tian-Shu Kang; Jia-Xin Liang; Chenfu Liu; Daniel W J Kwong; Vincent Kam Wai Wong; Dik-Lung Ma; Chung-Hang Leung
Journal:  Sci Rep       Date:  2016-11-17       Impact factor: 4.379

5.  Synthesis, Characterization, Cytotoxic Activity, and Interactions with CT-DNA and BSA of Cationic Ruthenium(II) Complexes Containing Dppm and Quinoline Carboxylates.

Authors:  Edinaldo N da Silva; Paulo A B da Silva; Angélica E Graminha; Pollyanna F de Oliveira; Jaqueline L Damasceno; Denise C Tavares; Alzir A Batista; Gustavo Von Poelhsitz
Journal:  Bioinorg Chem Appl       Date:  2017-07-26       Impact factor: 7.778

6.  New Heteroleptic Ruthenium(II) Complexes with Sulfamethoxypyridazine and Diimines as Potential Antitumor Agents.

Authors:  Ariane C C de Melo; Jaime M S V P Santana; Kelen J R C Nunes; Bernardo L Rodrigues; Nathalia Castilho; Philipe Gabriel; Adolfo H Moraes; Mayra de A Marques; Guilherme A P de Oliveira; Ívina P de Souza; Hernán Terenzi; Elene C Pereira-Maia
Journal:  Molecules       Date:  2019-06-07       Impact factor: 4.411
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.