Literature DB >> 24974343

Antiprotozoal activity of 8-acyl and 8-alkyl incomptine A analogs.

Elihú Bautista1, Fernando Calzada2, Fabiola A López-Huerta1, Lilian Yépez-Mulia3, Alfredo Ortega4.   

Abstract

The activities of 11 C-8-O-acyl and alkyl analogs of the antiprotozoal sesquiterpene lactone, incomptine A (1) against Entamoeba histolytica and Giardia lamblia, were determined. Here, the effects of different lengths and amounts of branching of the acyl and alkyl groups on the antiprotozoal activity of the synthesized incomptine A-analogs are reported.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antiprotozoal activity; Entamoeba histolytica; Giardia lamblia; Incomptine A analogs; Sesquiterpene lactones

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Year:  2014        PMID： 24974343     DOI： 10.1016/j.bmcl.2014.06.017

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Antilymphoma Effect of Incomptine A: In Vivo, In Silico, and Toxicological Studies.

Authors:  Fernando Calzada; Elihú Bautista; Sergio Hidalgo-Figueroa; Normand García-Hernández; Elizabeth Barbosa; Claudia Velázquez; Rosa María Ordoñez-Razo; Angel Giovanni Arietta-García
Journal:  Molecules       Date:  2021-11-02       Impact factor: 4.411

2.  Understanding the Anti-Diarrhoeal Properties of Incomptines A and B: Antibacterial Activity against Vibrio cholerae and Its Enterotoxin Inhibition.

Authors:  Fernando Calzada; Elihu Bautista; Sergio Hidalgo-Figueroa; Normand García-Hernández; Claudia Velázquez; Elizabeth Barbosa; Miguel Valdes; Jesús Iván Solares-Pascasio
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-03

Review 3.  Recent Advances in the Discovery of Novel Antiprotozoal Agents.

Authors:  Seong-Min Lee; Min-Sun Kim; Faisal Hayat; Dongyun Shin
Journal:  Molecules       Date:  2019-10-28       Impact factor: 4.411
  3 in total

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