Ryan E Childers1, Swathi Eluri2, Christine Vazquez3, Rayna Matsuno Weise4, Theodore M Bayless3, Susan Hutfless3. 1. Division of Gastroenterology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address: childerr@ohsu.edu. 2. Department of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA. 3. Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University, 600N Wolfe St, Baltimore, MD 21287, USA. 4. Bloomberg School of Public Health, Johns Hopkins University, USA.
Abstract
BACKGROUND AND AIMS: Despite numerous shared susceptibility loci between Crohn's disease and ulcerative colitis, the prevalence of family history among ulcerative colitis patients is not well-established and considered to be less prevalent. A systemic review and meta-analysis were conducted to estimate the prevalence of family history of inflammatory bowel disease in ulcerative colitis patients, and its effect on disease outcomes. METHODS: PubMED was searched to identify studies reporting the prevalence of family history of inflammatory bowel disease among ulcerative colitis patients. Definitions of family history, study type, and subtypes of family history prevalence were abstracted, as were disease outcomes including age at ulcerative colitis diagnosis, disease location, surgery and extraintestinal manifestations. Pooled prevalence estimates were calculated using random effects models. RESULTS: Seventy-one studies (86,824 patients) were included. The prevalence of a family history of inflammatory bowel disease in ulcerative colitis patients was 12% (95% confidence interval [CI] 11 to 13%; range 0-39%). Family history of ulcerative colitis (9%; 22 studies) was more prevalent than Crohn's disease (2%; 18 studies). Patients younger than 18years of age at time of diagnosis had a greater family history of inflammatory bowel disease (prevalence 15%, 95% CI: 11-20%; 13 studies). There were no differences in disease location, need for surgery, or extraintestinal manifestations among those with a family history, although very few studies reported on these outcomes. CONCLUSIONS: Overall, 12% of ulcerative colitis patients have a family history of inflammatory bowel disease, and were more likely to have a family history of ulcerative colitis than Crohn's disease. Pediatric-onset ulcerative colitis patients were more likely to have a family history of inflammatory bowel disease.
BACKGROUND AND AIMS: Despite numerous shared susceptibility loci between Crohn's disease and ulcerative colitis, the prevalence of family history among ulcerative colitispatients is not well-established and considered to be less prevalent. A systemic review and meta-analysis were conducted to estimate the prevalence of family history of inflammatory bowel disease in ulcerative colitispatients, and its effect on disease outcomes. METHODS: PubMED was searched to identify studies reporting the prevalence of family history of inflammatory bowel disease among ulcerative colitispatients. Definitions of family history, study type, and subtypes of family history prevalence were abstracted, as were disease outcomes including age at ulcerative colitis diagnosis, disease location, surgery and extraintestinal manifestations. Pooled prevalence estimates were calculated using random effects models. RESULTS: Seventy-one studies (86,824 patients) were included. The prevalence of a family history of inflammatory bowel disease in ulcerative colitispatients was 12% (95% confidence interval [CI] 11 to 13%; range 0-39%). Family history of ulcerative colitis (9%; 22 studies) was more prevalent than Crohn's disease (2%; 18 studies). Patients younger than 18years of age at time of diagnosis had a greater family history of inflammatory bowel disease (prevalence 15%, 95% CI: 11-20%; 13 studies). There were no differences in disease location, need for surgery, or extraintestinal manifestations among those with a family history, although very few studies reported on these outcomes. CONCLUSIONS: Overall, 12% of ulcerative colitispatients have a family history of inflammatory bowel disease, and were more likely to have a family history of ulcerative colitis than Crohn's disease. Pediatric-onset ulcerative colitispatients were more likely to have a family history of inflammatory bowel disease.
Authors: Priya Rangan; Inyoung Choi; Min Wei; Gerardo Navarrete; Esra Guen; Sebastian Brandhorst; Nobel Enyati; Gab Pasia; Daral Maesincee; Vanessa Ocon; Maya Abdulridha; Valter D Longo Journal: Cell Rep Date: 2019-03-05 Impact factor: 9.423
Authors: Cyrla Zaltman; Rogério Serafim Parra; Ligia Yukie Sassaki; Genoile Oliveira Santana; Maria de Lourdes Abreu Ferrari; Sender J Miszputen; Heda M B S Amarante; Roberto Luiz Kaiser Junior; Cristina Flores; Wilson R Catapani; José Miguel Luz Parente; Mauro Bafutto; Odery Ramos; Carolina D Gonçalves; Isabella Miranda Guimaraes; Jose J R da Rocha; Marley R Feitosa; Omar Feres; Rogerio Saad-Hossne; Francisco Guilherme Cancela Penna; Pedro Ferrari Sales Cunha; Tarcia Nf Gomes; Rodrigo Bremer Nones; Mikaell Alexandre Gouvea Faria; Mírian Perpétua Palha Dias Parente; António S Scotton; Rosana Fusaro Caratin; Juliana Senra; Júlio Maria Chebli Journal: World J Gastroenterol Date: 2021-01-14 Impact factor: 5.742