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Literature DB >> 24973460

Immunoglobulin genes influence the magnitude of humoral immunity to cytomegalovirus glycoprotein B.

Janardan P Pandey¹, Emily Kistner-Griffin², Faisal F Radwan¹, Navtej Kaur¹, Aryan M Namboodiri¹, Laurel Black¹, Mary Ann Butler³, Tania Carreón³, Avima M Ruder³.

Abstract

Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone is equally likely to develop HCMV-spurred diseases, implying the presence of host genetic factors that might modulate immunity to this virus. Here, we show that antibody responsiveness to HCMV glycoprotein B (gB) is significantly associated with particular immunoglobulin GM (γ marker) genotypes. Anti-HCMV gB antibody levels were highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 µg/mL, respectively; P=.014). These findings provide mechanistic insights in the etiopathogenesis of HCMV-spurred diseases.

Entities: Species

Keywords: GM allotypes; candidate genes; glycoprotein B; human cytomegalovirus; humoral immunity

Mesh：

Substances：

Year: 2014 PMID： 24973460 PMCID： PMC4296192 DOI： 10.1093/infdis/jiu367

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

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5. The Upper Midwest Health Study: a case-control study of primary intracranial gliomas in farm and rural residents.

Authors: A M Ruder; M A Waters; T Carreón; M A Butler; K E Davis-King; G M Calvert; P A Schulte; E M Ward; L B Connally; J Lu; D Wall; Z Zivkovich; E F Heineman; J S Mandel; R F Morton; D J Reding; K D Rosenman
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7. Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response.

Authors: T Kuparinen; I Seppälä; J Jylhävä; S Marttila; J Aittoniemi; J Kettunen; J Viikari; M Kähönen; O Raitakari; T Lehtimäki; M Hurme
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8. Identification and expression of human cytomegalovirus transcription units coding for two distinct Fcgamma receptor homologs.

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9. Genetic markers of immunoglobulin G and susceptibility to breast cancer.

Authors: Janardan P Pandey; Emily Kistner-Griffin; Motoki Iwasaki; Shizhong Bu; Ray Deepe; Laurel Black; Yoshio Kasuga; Gerson S Hamada; Shoichiro Tsugane
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10. Polymerase chain reaction-based genotyping for allotypic markers of immunoglobulin kappa shows allelic association of Km with kappa variable segment.

Authors: G Moxley; R S Gibbs
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12 in total

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Authors: Janardan P Pandey; Aryan M Namboodiri; Robert C Elston
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Authors: Janardan P Pandey; Aryan M Namboodiri; Paul J Nietert; Reiji Yoshimura; Hikaru Hori
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3. Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses.

Authors: Andrew R Crowley; Simone I Richardson; Marina Tuyishime; Madeleine Jennewein; Meredith J Bailey; Jiwon Lee; Galit Alter; Guido Ferrari; Lynn Morris; Margaret E Ackerman
Journal: Immunogenetics Date: 2022-07-29 Impact factor: 3.330

4. Association between γ marker, human leucocyte antigens and killer immunoglobulin-like receptors and the natural course of human cytomegalovirus infection: a pilot study performed in a Sicilian population.

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Review 5. Host Genetics of Cytomegalovirus Pathogenesis.

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Review 6. Immunoglobulin GM Genes, Cytomegalovirus Immunoevasion, and the Risk of Glioma, Neuroblastoma, and Breast Cancer.

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